{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:21:44Z","timestamp":1740126104464,"version":"3.37.3"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T00:00:00Z","timestamp":1534291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>While dermatoscopy improves diagnostic accuracy for raised nonpigmented lesions, those with white surface keratin can be problematical. We investigated whether retention of povidone\u2013iodine by surface keratin provides a clue to benignity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective pilot study (<jats:italic>n<\/jats:italic>\u00a0=\u00a057) followed by a prospective study (<jats:italic>n<\/jats:italic>\u00a0=\u00a0117) on raised nonpigmented lesions with white surface keratin. An initial dermatoscopic image was taken of each lesion, povidone\u2013iodine was applied and another image taken. Following lavage with 70% ethanol, a third image was acquired. The percentage surface area of residual povidone\u2013iodine staining after lavage was recorded, and the results analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The optimal cut\u2010off point of residual staining was 80%, where values of \u226480% pointed to malignancy. At this cut\u2010off, the <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> for lesions with values \u226480% to be truly malignant in the retrospective set was 4.03 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.1\u20137.6) and the <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> was 0.7 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.62\u20130.78). For the prospective set, the corresponding <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> was 2.3 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.4\u20133.7) and the <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> was 0.62 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.55\u20130.68).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study presents evidence that povidone\u2013iodine retention may have a degree of efficacy in distinguishing benign from malignant keratotic lesions. Further study is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12897","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T09:10:40Z","timestamp":1534324240000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A prospective diagnostic study on povidone\u2013iodine retention in lesions suspected to be squamous cell carcinoma or keratoacanthoma"],"prefix":"10.1111","volume":"60","author":[{"given":"Mariam","family":"Rizk","sequence":"first","affiliation":[{"name":"Faculty of Medicine The University of Queensland Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrnoosh","family":"Alian","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The University of Queensland Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Tschandl","sequence":"additional","affiliation":[{"name":"Department of Dermatology ViDIR Group Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madieh","family":"Gorgi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The University of Queensland Brisbane Queensland Australia"},{"name":"Sonic Skin Dx Macquarie Park New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3498-619X","authenticated-orcid":false,"given":"Matthew","family":"Hishon","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The University of Queensland Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Clark","sequence":"additional","affiliation":[{"name":"Sonic Skin Dx Macquarie Park New South Wales Australia"},{"name":"School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Kittler","sequence":"additional","affiliation":[{"name":"Department of Dermatology ViDIR Group Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5182-2969","authenticated-orcid":false,"given":"Clifford","family":"Rosendahl","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The University of Queensland Brisbane Queensland Australia"},{"name":"School of Medicine Tehran University of Medical Sciences Tehran 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