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There is rich potential for insight into the impact of dietary effects on the pathophysiology of inflammatory pilosebaceous disorders including acne vulgaris, hidradenitis suppurativa, rosacea, and the closely related seborrhoeic dermatitis. <jats:styled-content style=\"fixed-case\">Acne vulgaris<\/jats:styled-content> and hidradenitis suppurativa are thought to have similar diet\u2010modulating pathogenic pathways. Western diet influences Acne vulgaris and hidradenitis suppurativa by increasing insulin and modulating <jats:styled-content style=\"fixed-case\">FOX<\/jats:styled-content>01\/<jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content>, resulting in over\u2010expression of cytokeratins, hyperproliferation of keratinocytes, and hypercornification of the follicular wall. Key receptors in rosacea are alternatively activated by <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> radiation, hot beverages, spicy foods, vanilla, cinnamon, caffeine, alcohol, cold temperatures, and niacin\u2010 and formalin\u2010containing foods, to increase oedema and flushing, resulting in erythema, telangiectasia, and warmth, characteristic features of the condition. Seborrhoeic dermatitis, while not a follicular disorder, is closely related, and can be modulated by dietary influences, such as biotin and probiotics. This overview summarizes the role that nutrition plays on these disorders, and identifies dietary modifications as potential adjunctive therapies.<\/jats:p>","DOI":"10.1111\/ajd.12909","type":"journal-article","created":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T12:09:50Z","timestamp":1535976590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["The role of nutrition in inflammatory pilosebaceous disorders: Implication of the skin\u2010gut axis"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2732-6492","authenticated-orcid":false,"given":"Melody","family":"Maarouf","sequence":"first","affiliation":[{"name":"College of Medicine University of Arizona Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody F","family":"Platto","sequence":"additional","affiliation":[{"name":"College of Medicine University of Arizona Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7510-9428","authenticated-orcid":false,"given":"Vivian Y","family":"Shi","sequence":"additional","affiliation":[{"name":"Dermatology Division Department of Medicine University of Arizona Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,3]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/327452"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2013.05.005"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-015-0332-3"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.3920\/BM2012.0060"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12321.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1100330"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.06.045"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1677"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2009.07344_supp.x"},{"key":"e_1_2_4_11_1","unstructured":"Food sources of linoleic acid (PFA 18:2) listed in descending order by percentages of their contribution to intake based on data from the National Health and Nutrition Examination Survey 2005\u20102006. 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