{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:21:00Z","timestamp":1748913660913,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T00:00:00Z","timestamp":1536883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>The unknown pathogenesis of periorbital hyperpigmentation makes its treatment difficult. Existing evidence links <jats:italic>p53<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">VEGFA<\/jats:styled-content><\/jats:italic> genes with skin hyperpigmentation. This study was aimed at (i) identifying the clinical pattern of periorbital hyperpigmentation; and (ii) detecting the presence of <jats:italic><jats:styled-content style=\"fixed-case\">VEGFA<\/jats:styled-content><\/jats:italic> and <jats:italic>P53<\/jats:italic> single nucleotide polymorphism (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) in different subtypes of periorbital hyperpigmentation in Malaysian Chinese.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was conducted among Malaysian Chinese. Clinical assessments were performed, and medical history was collected. Three regions of <jats:italic>p53<\/jats:italic> and two of <jats:italic><jats:styled-content style=\"fixed-case\">VEGFA<\/jats:styled-content><\/jats:italic> were amplified by <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> followed by direct sequencing using saliva\u2010extracted <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010four participants were recruited (average age 22.2\u00a0years). In the majority (<jats:italic>n<\/jats:italic>\u00a0=\u00a062), both eyelids were affected. Facial pigmentary, demarcation lines, tear trough and eye bags were not observed. Mixed (pigmented\u2013vascular) was the most common subtype. Thirteen <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s were found, nine of which are new. Only three out of 13 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s showed significant association with periorbital hyperpigmentation presentation. <jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content> genotype in rs1437756379 (<jats:italic>p53<\/jats:italic>) was significantly more prevalent among participants with mixed subtype (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.011) while <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> genotype in rs1377053612 (<jats:italic><jats:styled-content style=\"fixed-case\">VEGFA<\/jats:styled-content><\/jats:italic>) was significantly more prevalent among pigmented subtype (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.028). <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> genotype in rs1479430148 (<jats:italic><jats:styled-content style=\"fixed-case\">VEGFA<\/jats:styled-content><\/jats:italic>) was significantly associated with allergic rhinitis in mixed subtype (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mixed subtype was the most prevalent type of periorbital hyperpigmentation in the study population. Three polymorphisms in <jats:italic>p53<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">VEGFA<\/jats:styled-content><\/jats:italic> genes were statistically linked with different clinical presentations of periorbital hyperpigmentation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12918","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T17:05:56Z","timestamp":1536944756000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Polymorphisms in P53 and <scp>VEGFA<\/scp> genes in different subtypes of periorbital hyperpigmentation in a Malaysian Chinese population"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9491-0851","authenticated-orcid":false,"given":"Farahnaz","family":"Amini","sequence":"first","affiliation":[{"name":"School of Healthy Aging, Medical Aesthetics and Regenerative Medicine Faculty of Medicine and Health Science UCSI University Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naw May","family":"Thazin Oo","sequence":"additional","affiliation":[{"name":"School of Healthy Aging, Medical Aesthetics and Regenerative Medicine Faculty of Medicine and Health Science UCSI University Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick Nwabueze","family":"Okechukwu","sequence":"additional","affiliation":[{"name":"Faculty of Applied Science UCSI University Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjan Sadat","family":"Seghayat","sequence":"additional","affiliation":[{"name":"School of Healthy Aging, Medical Aesthetics and Regenerative Medicine Faculty of Medicine and Health Science UCSI University Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmond Siah Chye","family":"Ng","sequence":"additional","affiliation":[{"name":"School of Healthy Aging, Medical Aesthetics and Regenerative Medicine Faculty of Medicine and Health Science UCSI University Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1969.01610260045007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05701.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-9-248"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73559"},{"key":"e_1_2_7_6_1","first-page":"49","article-title":"Periorbital hyperpigmentation: a comprehensive review","volume":"9","author":"Sarkar R","year":"2016","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805570200"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2012.02457.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02065.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.101371"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1684\/ecn.2009.0170"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2012.155"},{"key":"e_1_2_7_13_1","first-page":"185","article-title":"Genetic polymorphisms in the three malaysian races effect granisetron clinical antiemetic actions in breast cancer patients receiving chemotherapy","volume":"12","author":"Hassan BA","year":"2011","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"e_1_2_7_14_1","first-page":"187","article-title":"The essentiality of reporting Hardy\u2010Weinberg equilibrium calculations in population\u2010based genetic association studies","volume":"17","author":"Namipashaki A","year":"2015","journal-title":"Cell"},{"key":"e_1_2_7_15_1","first-page":"1","article-title":"Association between clinical characteristics, quality of life, and sleep quality in patients with periorbital hyperchromia","author":"Barone CR","year":"2018","journal-title":"J. Cosmet. Dermatol."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.12.045"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.03.006"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08624.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-012-9183-9"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13458"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2010.22.4.373"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-012-0048-2"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.01.009"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907550106"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-007-9074-0"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.4238\/gmr.15027880"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.028"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3867"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.127675"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.72"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.123492"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajd.12918","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.12918","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajd.12918","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.12918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T21:14:57Z","timestamp":1694294097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.12918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,14]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/ajd.12918"],"URL":"https:\/\/doi.org\/10.1111\/ajd.12918","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"type":"print","value":"0004-8380"},{"type":"electronic","value":"1440-0960"}],"subject":[],"published":{"date-parts":[[2018,9,14]]},"assertion":[{"value":"2018-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}