{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:10:31Z","timestamp":1787166631366,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Erosive oral lichen planus (<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>) may be painful and debilitating. Symptomatic <jats:styled-content style=\"fixed-case\">oral LP<\/jats:styled-content> has been treated with a wide spectrum of topical and systemic therapies, but few have been evaluated in large series. Hydroxychloroquine is suggested to be effective in <jats:styled-content style=\"fixed-case\">oral LP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010one consecutive patients with erosive, biopsy\u2010confirmed <jats:styled-content style=\"fixed-case\">oral LP<\/jats:styled-content> were prescribed. hydroxychloroquine sulphate 400 mg\/day. Symptomatic improvement was evaluated by means of a visual analogue scale into three groups: no change, moderate to marked improvement and complete remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five (24%) patients obtained complete remission, 12 (57%) patients showed moderate to marked improvement, 3 (14%) patients did not improve at all and in one patient therapy was terminated after 1 month due to side effects. Response to therapy was observed after 2\u20134 months. Side effects which ultimately led to termination of therapy in three patients were elevated creatinine serum levels (after 1 month), visual field defects (after 8 months) and hyperpigmentation (after 24 months). Among six patients who responded to therapy, three flared on stopping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hydroxychloroquine sulphate may be effective and relatively safe treatment for erosive <jats:styled-content style=\"fixed-case\">oral LP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12948","type":"journal-article","created":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T02:29:06Z","timestamp":1541730546000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Hydroxychloroquine sulphate therapy of erosive oral lichen planus"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1608-9527","authenticated-orcid":false,"given":"Algit","family":"Yeshurun","sequence":"first","affiliation":[{"name":"Department of Dermatology Rambam Medical Center Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuven","family":"Bergman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rambam Medical Center Haifa Israel"},{"name":"The Rappaport Faculty of Medicine Technion Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naji","family":"Bathish","sequence":"additional","affiliation":[{"name":"Ziv Medical Center Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Khamaysi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rambam Medical Center Haifa Israel"},{"name":"The Rappaport Faculty of Medicine Technion Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00946.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300405"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.18035"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2007.07.199"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12634"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247464"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.119648"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-007-0117-0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5676.138"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400402"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(91)90007-Y"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-6-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.00905.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200708020-00010"},{"key":"e_1_2_6_16_1","first-page":"310","article-title":"A single\u2010center, open\u2010label, prospective pilot study of subcutaneous efalizumab for oral erosive lichen planus","volume":"6","author":"Heffernan MP","year":"2007","journal-title":"J. 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