{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T03:20:52Z","timestamp":1768879252694,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"Abstract<\/jats:title>Background\/Objectives<\/jats:title>Psoriasis is one of the immune\u2010mediated inflammatory diseases where CD<\/jats:styled-content>4+ T lymphocytes, mainly Th1 cells, and B lymphocytes contribute in their pathogenesis through a pro\u2010inflammatory effect, production of antibodies, activation of T cells and cytokine synthesis. B and T lymphocyte attenuator (BTLA<\/jats:styled-content>) is a co\u2010inhibitory molecule expressed on T and B lymphocytes as well as other immune cells, and it is necessary to inhibit homoeostatic expansion and activation of lymph node and skin\u2010resident \u03b3\u03b4 T cells. BTLA<\/jats:styled-content> expression is regulated by ROR<\/jats:styled-content>\u03b3t and IL<\/jats:styled-content>\u20107. The study aimed at adding more insight on the role played by co\u2010inhibitory molecule BTLA<\/jats:styled-content> in psoriasis vulgaris and its inter\u2010relation with ROR<\/jats:styled-content>\u03b3t and IL<\/jats:styled-content>\u20107 to establish a basis for novel treatment strategies.<\/jats:p><\/jats:sec>Methods<\/jats:title>This case\u2013control study included 25 patients and 25 controls examined for gene expression of BTLA<\/jats:styled-content>, ROR<\/jats:styled-content>\u03b3t and IL<\/jats:styled-content>\u20107.<\/jats:p><\/jats:sec>Results<\/jats:title>B and T lymphocyte attenuator was significantly lower in psoriasis patients, whereas both ROR<\/jats:styled-content>\u03b3t and IL<\/jats:styled-content>\u20107 were higher in comparison with controls. A significant positive<\/jats:italic> correlation between disease severity (PASI<\/jats:styled-content>) and both ROR<\/jats:styled-content>\u03b3t and IL<\/jats:styled-content>\u20107 as well as between ROR<\/jats:styled-content>\u03b3t and IL<\/jats:styled-content>\u20107 was found. A significant negative<\/jats:italic> correlation between BTLA<\/jats:styled-content> and both ROR<\/jats:styled-content>\u03b3t and IL<\/jats:styled-content>\u20107 was found. Neither the age nor the duration of disease had any correlation with BTLA<\/jats:styled-content>, ROR<\/jats:styled-content>\u03b3t or IL<\/jats:styled-content>\u20107. BTLA<\/jats:styled-content> had no correlation with PASI<\/jats:styled-content>. Regarding the control group, a significant negative correlation between ROR<\/jats:styled-content>\u03b3t and IL<\/jats:styled-content>\u20107 was found.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>B and T lymphocyte attenuator, ROR<\/jats:styled-content>\u03b3t and IL<\/jats:styled-content>\u20107 play an important role in psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12965","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T06:55:42Z","timestamp":1548312942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Expression of B and T lymphocyte attenuator, retinoid\u2010related orphan receptor gamma\u2010isoform\u2010t and interleukin 7 in psoriasis vulgaris"],"prefix":"10.1111","volume":"60","author":[{"given":"Randa Mohammed","family":"Youssef","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amany Zaki","family":"El\u2010Ramly","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7671-3803","authenticated-orcid":false,"given":"Marwa Fathy","family":"Hussien","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia Mohamed","family":"Shoukry","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Research Centre Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalda","family":"Amr","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics National Research Centre Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.194"},{"key":"e_1_2_7_3_1","first-page":"664","article-title":"Immune\u2010mediated inflammatory disorders (I.M.I.D.s): the economic and clinical costs","volume":"8","author":"Williams JP","year":"2002","journal-title":"Am. 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