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We searched PubMed (Medline), Central, Embase, Web of Science and <jats:styled-content style=\"fixed-case\">EBSCO<\/jats:styled-content>host (until May 2018) for the eligible studies reporting more than 10 <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> patients who were treated with oral atenolol with detailed original data, including outcomes, regimens and adverse events (<jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s). The data was standardised and analysed by using R software with meta\u2010package. A total of 9 of 141 identified articles, including 341 infantile haemangioma patients treated with oral atenolol therapy, were included. The pooled response rate of atenolol was 0.90 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.85\u20130.93), and the rebound rate was 0.11 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.08\u20130.16). Among the 341 patients, 44 patients were switched to atenolol therapy from propranolol due to adverse events. The response rate of subsequent atenolol treatment was 90.9% (40\/44). Regarding <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s, 141 patients reported 177 episodes of <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s, and the pooled rate was 0.26 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.12\u20130.47). Gastrointestinal symptoms (e.g. constipation, diarrhoea and vomiting) were the most frequent <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s (22.6%). Widely known propranolol\u2010related <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s, including hypoglycaemia, bronchospasm, bradycardia and hypotension, were not recorded. Overall, atenolol appears to be an effective and safe therapy for the treatment of <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> and may be a promising alternative to propranolol.<\/jats:p>","DOI":"10.1111\/ajd.12966","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T01:40:10Z","timestamp":1543974010000},"page":"181-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy and safety of oral atenolol for the treatment of infantile haemangioma: A systematic review"],"prefix":"10.1111","volume":"60","author":[{"given":"Qi","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Oncology Department of Pediatric Surgery West China Hospital of Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Xiang","sequence":"additional","affiliation":[{"name":"Division of Oncology Department of Pediatric Surgery West China Hospital of Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit Department of Critical Care Medicine West China Hospital of Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9289-9660","authenticated-orcid":false,"given":"Yi","family":"Ji","sequence":"additional","affiliation":[{"name":"Division of Oncology Department of Pediatric Surgery West China Hospital of Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-2485"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1691"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404710"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-0353"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2016.1130125"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00645-0"},{"key":"e_1_2_7_8_1","first-page":"1","article-title":"When to stop propranolol for infantile hemangioma","volume":"7","author":"Chang L","year":"2017","journal-title":"Sci. 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