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What may not be appreciated is that darker\u2010skinned individuals may also carry melanocortin 1 receptor variant alleles and that they can also be at increased risk of melanoma. Considering that melanocortin 1 receptor is crucial for melanocyte proliferation, regulation and differentiation do the naevi of these darker\u2010skinned individuals have specific features that help identify them as carrying one of these melanocortin 1 receptor variants and do melanomas that develop in dark\u2010skinned melanocortin 1 receptor variant carriers have particular characteristics?<\/jats:p>","DOI":"10.1111\/ajd.12982","type":"journal-article","created":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T04:20:54Z","timestamp":1545798054000},"page":"192-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Melanocortin 1 receptor and its influence on naevi and melanoma in dark\u2010skinned phenotypes"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6276-2508","authenticated-orcid":false,"given":"David John Mackay","family":"Smith","sequence":"first","affiliation":[{"name":"University of Queensland Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,25]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-328"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/302863"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071144"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2007.03.004"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.3.351"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0233"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.7.845"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08404.x"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13467"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.02.012"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-09-0108"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/302494"},{"key":"e_1_2_15_14_1","first-page":"520","article-title":"Heritability and gene\u2010environment interactions for melanocytic density examined in a UK adolescent study","volume":"130","author":"Wachmuth R","year":"2010","journal-title":"J.Invest. 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