{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:37:14Z","timestamp":1747183034297,"version":"3.40.5"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Muir Torre syndrome is an autosomal dominant disorder characterised by germline mutations in mismatch repair genes involved in <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> repair, leading to microsatellite instability and a propensity to tumour formation. We report a case of a 67\u2010year\u2010old gentleman who underwent biopsy of a smooth nodular lesion on the nasal tip, histopathologically consistent with sebaceous adenoma. Immunohistochemistry suggested a loss of <jats:styled-content style=\"fixed-case\">MSH<\/jats:styled-content>6. Subsequent colonoscopy identified a poorly differentiated adenocarcinoma, with loss of staining for <jats:styled-content style=\"fixed-case\">MSH<\/jats:styled-content>6 and a germline mutation identified on genetic analysis. These findings were consistent with a diagnosis of Muir Torre syndrome. Whilst there is controversy in the literature regarding universal screening for Muir Torre syndrome, the early detection of visceral neoplasms is crucial. The authors strongly support screening for Muir Torre syndrome (with patient consent) upon discovery of a cutaneous sebaceous neoplasm, even in the absence of a personal or family history of visceral malignancy.<\/jats:p>","DOI":"10.1111\/ajd.12989","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T06:49:34Z","timestamp":1548312574000},"page":"234-236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiple benign adnexal tumours: Anything but benign"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9556-691X","authenticated-orcid":false,"given":"Rose\u2010Lynn","family":"McCarthy","sequence":"first","affiliation":[{"name":"St Vincent's Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte L","family":"Thomas","sequence":"additional","affiliation":[{"name":"St Vincent's Hospital Sydney New South Wales Australia"},{"name":"The Skin Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Isaacs","sequence":"additional","affiliation":[{"name":"St Vincent's Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5070\/D3666004S1","article-title":"Immunohistochemistry screening of sebaceous lesions for Muir\u2010Torre syndrome in a 26\u2010year period in a Mexican population","volume":"14","author":"Archer\u2010Dubon C","year":"2008","journal-title":"Dermatol. 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