{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:28Z","timestamp":1787013808062,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Calciphylaxis is a rare but life\u2010threatening condition, most commonly affecting patients with stage 4 or 5 chronic kidney disease. No universally accepted therapy exists so far. In an attempt to avoid surgical intervention with parathyroidectomy, which is of questionable efficacy and carries several risks, a number of noninvasive treatments have been trialled with variable success. These treatments are aimed at modifying risk factors for calciphylaxis, in particular hypercalcaemia, hyperphosphataemia and hyperparathyroidism. The aim of this review was to summarise the available evidence to determine the potential role of cinacalcet in the treatment of calciphylaxis in patients with chronic kidney disease. Demographic, clinical and laboratory data were retrospectively collected from the available English and non\u2010English literature. Overall, there was a very high response rate (partial or complete) of calciphylaxis lesions to both cinacalcet monotherapy and cinacalcet as part of a combination therapy (83.4% and 82.8%, respectively). When examining complete response to treatment specifically, combination therapy with cinacalcet proved more efficacious than monotherapy (62.1% versus 41.7%). There was also an associated rapid reduction of intact parathyroid hormone over a period of 2\u201333 months in both groups. While there are limitations as to how our data can be interpreted due to the heterogeneity of the methods and follow\u2010up of the included case reports and case series, prompt and consistent therapy including cinacalcet may help improve the disease outcome. Additional research needs to be performed in this area, to further define the optimal use of cinacalcet for the treatment of calciphylaxis.<\/jats:p>","DOI":"10.1111\/ajd.12992","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:46:45Z","timestamp":1548118005000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The use of cinacalcet for the treatment of calciphylaxis in patients with chronic kidney disease: A comprehensive review"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8935-6673","authenticated-orcid":false,"given":"Jacqueline","family":"Deen","sequence":"first","affiliation":[{"name":"Sunshine Coast University Hospital Birtinya Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Schaider","sequence":"additional","affiliation":[{"name":"Department of Dermatology Princess Alexandra Hospital Brisbane Queensland Australia"},{"name":"Dermatology Research Centre The University of Queensland Diamantina Institute The University of Queensland Brisbane Queensland Australia"},{"name":"Department of Dermatology The Townsville Hospital and Health Service Townsville Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4314\/ajnt.v3i1.57600"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp070546"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs548"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJNRD.S78310"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10221014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07540.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm676"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v32.pm9740152"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v32.pm9740153"},{"key":"e_1_2_8_11_1","first-page":"575","article-title":"The calcimimetic AMG 073 reduces parathyroid hormone and calcium x phosphate in secondary hyperparathyroidism","volume":"14","author":"Linberg JS","year":"2003","journal-title":"Kidney Int."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031633"},{"key":"e_1_2_8_13_1","first-page":"55","article-title":"Controversies in chronic kidney disease staging","volume":"32","author":"Polkinghorne KR","year":"2011","journal-title":"Clin. 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