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We report here two cases with treatment\u2010resistant prurigo that were successfully treated with duloxetine hydrochloride, a serotonin\u2013norepinephrine reuptake inhibitor. <jats:italic>In vivo<\/jats:italic> experiments with a mouse model of prurigo\u2010like inflammation showed that duloxetine hydrochloride ameliorated not only scratching behaviours, but also skin inflammation. Duloxetine hydrochloride appears to be useful for treating prurigo via modulating itch signals and immune responses.<\/jats:p>","DOI":"10.1111\/ajd.12996","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T21:21:52Z","timestamp":1548364912000},"page":"237-239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prurigo successfully treated with duloxetine hydrochloride"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6779-5598","authenticated-orcid":false,"given":"Takashi","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Department of Dermatology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"},{"name":"Department of Dermatology National Defense Medical College Tokorozawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2244-6332","authenticated-orcid":false,"given":"Takahiro","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Defense Medical College Tokorozawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5773-9485","authenticated-orcid":false,"given":"Hiroo","family":"Yokozeki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2774"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.1.29"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02570.x"},{"key":"e_1_2_6_5_1","first-page":"1","article-title":"Possible roles of Basophils in chronic itch","author":"Hashimoto T","year":"2018","journal-title":"Exp. 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