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The latter is due to an unresolved uncertainty regarding its biological nature which necessitates further clarification. Recent molecular genetics, epigenetic and transcriptomic discoveries have revealed that a subset of dysplastic naevi exhibits a genomic profile which is intermediate between that of benign naevus and melanoma. This group of lesions often shows somatic mutations in non\u2010<jats:italic>V600E <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> NRAS<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">TERT<\/jats:styled-content><\/jats:italic> and hemizygous deletion of <jats:italic><jats:styled-content style=\"fixed-case\">CDKN<\/jats:styled-content>2A<\/jats:italic> gene as well as upregulation of genes involved in proliferation, cell adhesion and migration, and epidermal and follicular keratinocyte\u2010related genes. These new genomic insights suggest that a proportion of dysplastic naevi have a greater propensity to evolve to melanoma; however, the clinical and histopathological features of this proposed intermediate category are still to be elucidated by further research.<\/jats:p>","DOI":"10.1111\/ajd.13019","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T01:55:26Z","timestamp":1552269326000},"page":"186-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Dysplastic\/Clark naevus in the era of molecular pathology"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9477-8291","authenticated-orcid":false,"given":"Nima","family":"Mesbah Ardakani","sequence":"first","affiliation":[{"name":"Department of Anatomical Pathology PathWest Laboratory Medicine QEII Medical Centre Perth Western Australia Australia"},{"name":"School of Pathology and Laboratory Medicine University of Western Australia Perth Western Australia Australia"},{"name":"School of Veterinary and Life Science Murdoch University Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,10]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1001\/archderm.1978.01640170032006"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1016\/j.jaad.2015.06.061"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1111\/ajd.12720"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/00006534-198106000-00103","article-title":"Dysplastic nevus syndrome: a phenotypic association of sporadic cutaneous melanoma","volume":"67","author":"Mladick RA","year":"1981","journal-title":"Plast. 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