{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:03:42Z","timestamp":1780700622732,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T00:00:00Z","timestamp":1554768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">BIOCHIP<\/jats:styled-content> (Dermatology Mosaic 7, EUROIMMUN, Lubeck, Germany) is a novel multiplex indirect immunofluorescence technique used in the serological diagnosis of bullous pemphigoid. The BIOCHIP method combines the screening of several autoantibodies and target antigen\u2010specific substrates in a single miniature incubation field to allow for simultaneous processing of the most common autoimmune bullous diseases autoantibodies using a single investigation. This manuscript reviews the literature on the validity of the <jats:styled-content style=\"fixed-case\">BIOCHIP<\/jats:styled-content> in the diagnosis of bullous pemphigoid. A systematic search for journal articles comparing the sensitivity and specificity of diagnostic tests for bullous pemphigoid patients was conducted in online databases via the Ovid <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content> search interfaces. The literature search generated 745 articles of which 189 were deemed relevant. Among the relevant articles, seven studies investigated the validity of the <jats:styled-content style=\"fixed-case\">BIOCHIP<\/jats:styled-content> indirect immunofluorescent test in the diagnosis of bullous pemphigoid. The <jats:styled-content style=\"fixed-case\">BIOCHIP<\/jats:styled-content> has demonstrated itself to be a specific test for <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 (96.5\u2013100%) and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>230 (98.3\u2013100%), with a high sensitivity for <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 (83.3\u2013100%) but poor sensitivity for <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>230 (24.3\u201366.7%). The <jats:styled-content style=\"fixed-case\">BIOCHIP<\/jats:styled-content> mosaic\u2010based immunofluorescence test is potentially a simple, time\u2010 and effort\u2010saving test that can aid in the diagnosis and screening of bullous pemphigoid. Further studies should report on the inter\u2010rater reliability of the <jats:styled-content style=\"fixed-case\">BIOCHIP<\/jats:styled-content> to further validate the tool.<\/jats:p>","DOI":"10.1111\/ajd.13034","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:05:32Z","timestamp":1554854732000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A new indirect immunofluorescence <scp>BIOCHIP<\/scp> method for the serological diagnosis of bullous pemphigoid: A review of literature"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9184-5484","authenticated-orcid":false,"given":"Anes","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Dermatology St George Hospital Sydney New South Wales Australia"},{"name":"Faculty of Medicine University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Xuan","sequence":"additional","affiliation":[{"name":"Department of Dermatology St George Hospital Sydney New South Wales Australia"},{"name":"Faculty of Medicine University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dedee F","family":"Murrell","sequence":"additional","affiliation":[{"name":"Department of Dermatology St George Hospital Sydney New South Wales Australia"},{"name":"Faculty of Medicine University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113803"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12616580"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.4390"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.6896.1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339776"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70094-X"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06006.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(02)00109-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06082.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2004.10.007"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.23"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.07.009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03824.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.07.006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2003.12.007"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04630.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337545"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.2.174"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2012.05.007"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2017.65617"},{"key":"e_1_2_7_22_1","first-page":"202","article-title":"The value of the BIOCHIP mosaic\u2010based indirect immunofluorescence technique in the diagnosis of pemphigus and bullous pemphigoid in Turkish patients","volume":"25","author":"Ozkesici B","year":"2017","journal-title":"Acta Dermatovenerol. 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