{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T07:36:00Z","timestamp":1778312160988,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["KF2017009"],"award-info":[{"award-number":["KF2017009"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hidradenitis suppurativa is a chronic skin disease characterised by repeated skin abscesses with sinus tracts and scar formation. Currently, the aetiology and pathogenesis of hidradenitis suppurativa remain unclear. Genetic factors, immune disorders, hormonal abnormalities, skin\u2010microbial dysbiosis, smoking, obesity and mechanical friction all influence hidradenitis suppurativa pathogenesis. Moreover, hidradenitis suppurativa has a familial subset with autosomal dominant transmission proposed and is related to a mutation of \u03b3\u2010secretase component genes. In this\u00a0review, we analyse and summarise research progress regarding the relationship between the \u03b3\u2010secretase gene dysfunction and the pathogenesis of hidradenitis suppurativa.<\/jats:p>","DOI":"10.1111\/ajd.13107","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T23:46:01Z","timestamp":1562111161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A gene dysfunction module reveals the underlying pathogenesis of hidradenitis suppurativa: An update"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3644-2594","authenticated-orcid":false,"given":"Xueli","family":"Li","sequence":"first","affiliation":[{"name":"Department of Aesthetic, Plastic, and Burn Surgery Yuhuangding Hospital Affiliated Hospital of Qingdao University Yantai City Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Aesthetic, Plastic, and Burn Surgery Yuhuangding Hospital Affiliated Hospital of Qingdao University Yantai City Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Aesthetic, Plastic, and Burn Surgery Yuhuangding Hospital Affiliated Hospital of Qingdao University Yantai City Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhilong","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Aesthetic, Plastic, and Burn Surgery Yuhuangding Hospital Affiliated Hospital of Qingdao University Yantai City Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqin","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Aesthetic, Plastic, and Burn Surgery Yuhuangding Hospital Affiliated Hospital of Qingdao University Yantai City Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Aesthetic, Plastic, and Burn Surgery Yuhuangding Hospital Affiliated Hospital of Qingdao University Yantai City Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06492.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.15570\/actaapa.2018.5"},{"key":"e_1_2_6_4_1","first-page":"162","article-title":"Advances in clinical classification, concomitant diseases and complications of acne vulgaris","volume":"43","author":"Zheng LY","year":"2017","journal-title":"Int. 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