{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:23:19Z","timestamp":1762899799751,"version":"3.30.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Members of the interleukin (IL<\/jats:styled-content>)\u201036 family, IL<\/jats:styled-content>\u201036\u03b1, IL<\/jats:styled-content>\u201036\u03b2 and IL<\/jats:styled-content>\u201036\u03b3, are potent chemoattractive cytokines for neutrophils and eosinophils. IL<\/jats:styled-content>\u201036 receptor antagonist (IL<\/jats:styled-content>\u201036Ra) inhibits IL<\/jats:styled-content>\u201036\u03b1, IL<\/jats:styled-content>\u201036\u03b2 and IL<\/jats:styled-content>\u201036\u03b3 activity. However, the immunohistological expression of IL<\/jats:styled-content>\u201036\u03b1, IL<\/jats:styled-content>\u201036\u03b2, IL<\/jats:styled-content>\u201036\u03b3 and IL<\/jats:styled-content>\u201036Ra has never been addressed in normal follicles, folliculitis or eosinophilic pustular folliculitis (EPF<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We performed immunohistochemical staining for IL<\/jats:styled-content>\u201036\u03b1, IL<\/jats:styled-content>\u201036\u03b2, IL<\/jats:styled-content>\u201036\u03b3 and IL<\/jats:styled-content>\u201036Ra using 10 cases of EPF<\/jats:styled-content>, nine of non\u2010specific folliculitis, 10 normal skin samples and 10 samples of normal follicles adjacent to a sebaceous naevus as a control. Two dermatologists, who were blind to the patient records, evaluated all of the slides.<\/jats:p><\/jats:sec>Results<\/jats:title>The immunoreactive IL<\/jats:styled-content>\u201036\u03b1 was hardly detected in the follicular epithelium and epidermis in the normal skin, folliculitis or EPF<\/jats:styled-content>. The expression of IL<\/jats:styled-content>\u201036\u03b2, IL<\/jats:styled-content>\u201036\u03b3 and IL<\/jats:styled-content>\u201036Ra was augmented in both folliculitis and EPF<\/jats:styled-content> compared with that in normal follicles. Negative correlations were detected between IL<\/jats:styled-content>\u201036\u03b2 and IL<\/jats:styled-content>\u201036Ra and between IL<\/jats:styled-content>\u201036\u03b3 and IL<\/jats:styled-content>\u201036Ra in normal follicles; however, these were absent in folliculitis. In contrast to normal follicles and folliculitis, a significant positive correlation between IL<\/jats:styled-content>\u201036\u03b2\/\u03b3 and IL<\/jats:styled-content>\u201036Ra was shown in EPF<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The overexpression of IL<\/jats:styled-content>\u201036\u03b2, IL<\/jats:styled-content>\u201036\u03b3 and IL<\/jats:styled-content>\u201036Ra is an integral part of the inflammatory response of folliculitis and EPF<\/jats:styled-content>. The coordinated expression of IL<\/jats:styled-content>\u201036\u03b3 and IL<\/jats:styled-content>\u201036Ra may be related to the pathomechanism of EPF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13143","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T12:07:58Z","timestamp":1566216478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Upregulation of IL<\/scp>\u201036 cytokines in folliculitis and eosinophilic pustular folliculitis"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1328-2452","authenticated-orcid":false,"given":"Seisho","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Dermatology Graduate School of Medical Sciences Kyushu University Fukuoka 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