{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:34:33Z","timestamp":1791484473405,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It acknowledged that skin care is an important part of atopic dermatitis therapy. However, clinical evidences are limited for the best bathing practices, especially the skin health performance of cleansing products on children's atopic dermatitis skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomised controlled clinical study was conducted in China among 4\u2010 to 18\u2010year\u2010old children with mild\u2010to\u2010moderate atopic dermatitis to evaluate the skin health effect of three cleansing systems (a mild synthetic bar, an ultra\u2010mild body wash with lipids, and an ultra\u2010mild body wash with lipids and zinc pyrithione) by measuring SCORing of Atopic Dermatitis (SCORAD), consumption of topical corticosteroid and the characteristics of microbiome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increased <jats:italic>Staphylococcus aureus<\/jats:italic> abundance and decreased microbial diversity were observed in atopic dermatitis lesion sites compared with healthy control sites. After 4\u00a0weeks of treatment, all three treatments showed clinically important improvement from baseline in SCORAD. Four\u2010week corticosteroid consumption was significantly lower for the two body wash groups than the bar group. A significant decrease in <jats:italic>S.\u00a0aureus<\/jats:italic> abundance and increase in microbial diversity were observed in the lesion sites for the two body wash formulas, while the microbial diversity was statistically insignificant for the mild cleansing bar group. However, there were no incremental benefits provided by the body wash formulas based on the assessment of SCORAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results demonstrated the safety and efficacy of using the investigational body wash formulas with lipids in reducing the needs for corticosteroid and improving the healthy composition of skin microbiome vs. the mild synthetic bar soap.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13153","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T06:29:33Z","timestamp":1568269773000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Skin benefits of moisturising body wash formulas for children with atopic dermatitis: A randomised controlled clinical study in China"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8645-1854","authenticated-orcid":false,"given":"Zigang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Dermatology Beijing Children's Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Capital Institute of Pediatrics Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqing","family":"Niu","sequence":"additional","affiliation":[{"name":"Procter &amp; Gamble Beijing Innovation Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunping","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Children's Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Heminger","sequence":"additional","affiliation":[{"name":"Procter &amp; Gamble Mason Business Center Mason Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Moulton","sequence":"additional","affiliation":[{"name":"Procter &amp; Gamble Mason Business Center Mason Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Yu","sequence":"additional","affiliation":[{"name":"Procter &amp; Gamble Beijing Innovation Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Allen","sequence":"additional","affiliation":[{"name":"Procter &amp; Gamble Mason Business Center Mason Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Procter &amp; Gamble Beijing Innovation Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yue","sequence":"additional","affiliation":[{"name":"Procter &amp; Gamble Beijing Innovation Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiquan","family":"Liu","sequence":"additional","affiliation":[{"name":"Procter &amp; Gamble Singapore Innovation Center Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"Procter &amp; Gamble Singapore Innovation Center Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Procter &amp; 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