{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:31:36Z","timestamp":1762507896970,"version":"3.30.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Melanoma may develop <jats:italic>de novo<\/jats:italic> or naevus associated (<jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content>). The exact prevalence and features of <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content> are not fully elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 15\u2010year cross\u2010sectional retrospective study was performed of\u00a0all melanoma cases diagnosed and treated at the skin cancer centre of the University of Naples Federico <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> from September 2003 to August 2018. Data collected included\u00a0patient's age, gender, melanoma anatomic site, Breslow thickness, and\u00a0histolopathology including melanoma\u2010associated lesion characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1986 melanomas were included in the study. Based on histolopathogical examination, <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content> represented 8.4% (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>167) with de novo melanoma\u00a0representing the great majority of the melanomas (91.6%). <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content> was significantly more common in younger age compared to de novo melamoma (mean age 48\u00a0\u00b1\u00a014.9 vs 54.3\u00a0\u00b1\u00a015.9\u00a0years, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), and more frequently involved the trunk (62.3% vs 51.8% <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.01). Mean Breslow thickness was significantly higher in de novo melanoma\u00a0 compared to <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content> (0.97\u00a0\u00b1\u00a01.48\u00a0mm vs 0.83\u00a0\u00b1\u00a00.95, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). However, <jats:italic>in situ<\/jats:italic> melanoma was more commonly observed in de novo melanoma (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>640, 35.2%) rather than <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content> (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>41, 24.5%; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01) whereas invasive melanoma represented 75.5% (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>126) of <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content> and 64.8% (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>1179) of de novo melanoma,<jats:italic> P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content> represent a small percentage of melanomas (8.4%) compared to de novo melanoma. <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content> appeared to be significantly more common in younger age and more frequently involved the trunk, being associated with an overall better prognosis, due to a lower mean Breslow thickness respect to de novo melanoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13171","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T12:47:30Z","timestamp":1570798050000},"page":"39-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cutaneous melanoma associated with naevi prevalence: A 15\u2010year cross\u2010sectional retrospective study"],"prefix":"10.1111","volume":"61","author":[{"given":"Massimiliano","family":"Scalvenzi","sequence":"first","affiliation":[{"name":"Section of Dermatology Department of Clinical Medicine and Surgery University of Naples Federico II Naples 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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6430-268X","authenticated-orcid":false,"given":"Alessia","family":"Villani","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Clinical Medicine and Surgery University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9511-1077","authenticated-orcid":false,"given":"Vincenzo","family":"Greco","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Clinical Medicine and Surgery University of Naples Federico II Naples 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