{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:01:51Z","timestamp":1790096511756,"version":"4.0.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"crossref","award":["940099"],"award-info":[{"award-number":["940099"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Side effects of current treatments and the need for a safe treatment with higher efficiency necessitate seeking new treatment options for vitiligo. Few studies have investigated the combination of psoralen with narrowband ultraviolet B (<jats:styled-content style=\"fixed-case\">NBUVB<\/jats:styled-content>). In this study, we compared the efficacy and safety of psoralen and <jats:styled-content style=\"fixed-case\">NBUVB<\/jats:styled-content> combination (P\u2010<jats:styled-content style=\"fixed-case\">NBUVB<\/jats:styled-content>) with <jats:styled-content style=\"fixed-case\">NBUVB<\/jats:styled-content> alone in treatment of vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomised clinical trial was carried out during 2015\u20132017 in dermatology clinics of Ghaem and Imam Reza hospitals, Mashhad, Iran on 40 vitiligo patients with 5\u201360% body involvement. The patients were randomly divided into two groups of <jats:styled-content style=\"fixed-case\">NBUVB<\/jats:styled-content> alone and P\u2010<jats:styled-content style=\"fixed-case\">NBUVB<\/jats:styled-content>. Both groups underwent 60 phototherapy sessions (three sessions per week), and the repigmentation rate was measured using vitiligo area severity index (<jats:styled-content style=\"fixed-case\">VASI<\/jats:styled-content>) score. <jats:styled-content style=\"fixed-case\">SPSS<\/jats:styled-content> v. 16 software and appropriate statistical tests were used to analyse the data. <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of patients was 33.9\u00a0\u00b1\u00a011.3\u00a0years. Twenty patients (50%) were females. The P\u2010<jats:styled-content style=\"fixed-case\">NBUVB<\/jats:styled-content> group showed greater <jats:styled-content style=\"fixed-case\">VASI<\/jats:styled-content> improvement in lower extremities (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.003) and overall (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.026) compared with <jats:styled-content style=\"fixed-case\">NBUVB<\/jats:styled-content> group. Moreover, the treatment response appeared sooner in P\u2010<jats:styled-content style=\"fixed-case\">NUVB<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on our results, we can conclude that adding psoralen to <jats:styled-content style=\"fixed-case\">NBUVB<\/jats:styled-content> phototherapy can result in increased efficacy. However, more studies are needed to evaluate the long\u2010term effects and side effects of this treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13184","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T10:03:15Z","timestamp":1571997795000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Psoralen and narrowband <scp>UVB<\/scp> combination provides higher efficacy in treating vitiligo compared with narrowband <scp>UVB<\/scp> alone: A randomised clinical trial"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2359-5313","authenticated-orcid":false,"given":"Naghmeh","family":"Zabolinejad","sequence":"first","affiliation":[{"name":"Cutaneous Leishmaniasis Research Center Mashhad University of medical sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Maleki","sequence":"additional","affiliation":[{"name":"Cutaneous Leishmaniasis Research Center Mashhad University of medical sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Salehi","sequence":"additional","affiliation":[{"name":"Department of Community Medicine School of Medicine Mashhad University of medical sciences Mashhad Iran"},{"name":"Research Center for Patient Safety Mashhad University of medical sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Ashrafi","sequence":"additional","affiliation":[{"name":"Cutaneous Leishmaniasis Research Center Mashhad University of medical sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Molkara","sequence":"additional","affiliation":[{"name":"Cutaneous Leishmaniasis Research Center Mashhad University of medical sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8286-0922","authenticated-orcid":false,"given":"Pouran","family":"Layegh","sequence":"additional","affiliation":[{"name":"Cutaneous Leishmaniasis Research Center Mashhad University of medical sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.11.061"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01139.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2009.04.008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.5.578"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2011.00606.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00174.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1982.tb00293.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1994.tb02895.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.5070\/D37Z00P9DM"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2006.00189.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2010.01345.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12072"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.6.677"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0781.2001.170403.x"},{"key":"e_1_2_6_16_1","first-page":"30","article-title":"Treatment of vitiligo with narrow band UVB vs. UVB with 0.1% psoralin; A case controlled, comparative, therapeutic trial","volume":"1","author":"Al\u2010Saedy SJ","year":"2012","journal-title":"Am. 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