{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:30:39Z","timestamp":1783452639180,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Palmoplantar psoriasis is a localised variant of psoriasis. Topical therapy is the preferred treatment modality, but in severe and recalcitrant cases, systemic drugs like methotrexate are prescribed, with potential for significant adverse effects. Iontophoresis is gaining popularity in enhancing the transdermal delivery of drugs in ionic state. This study was undertaken to evaluate and compare the efficacy of topical methotrexate by iontophoresis technique with clobetasol propionate 0.05% ointment in the treatment of palmar psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective randomised controlled study conducted on patients with palmar psoriasis. Group 1 patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a031) were treated with once weekly iontophoretic delivery of methotrexate over 6 sittings, and group 2 patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a031) were treated with clobetasol propionate 0.05% ointment, twice daily for 6\u00a0weeks. Severity of palmar psoriasis was assessed by modified Palmoplantar Pustular Psoriasis Area and Severity Index (m\u2010PPPASI), and treatment was considered as satisfactory when there was &gt;50% improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty two patients were recruited, of which 50 completed the study. Eight out of 25 (32%) patients in group 1 and 12 out of 25 (48%) patients in group 2 showed satisfactory improvement at the end of 6\u00a0weeks. However, this difference was statistically not significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.25). Burn injury was noted in 12 (48%) group 1 patients with no adverse effects in group 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Iontophoretic delivery of methotrexate is a promising therapeutic modality, the efficacy of which is comparable to that of clobetasol propionate ointment in the treatment of palmar psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13228","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T08:52:38Z","timestamp":1579164758000},"page":"140-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Iontophoretic delivery of methotrexate in the treatment of palmar psoriasis: A randomised controlled study"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5442-1615","authenticated-orcid":false,"given":"Naveen Kumar","family":"Andanooru Chandrappa","sequence":"first","affiliation":[{"name":"Department of D.V.L Hassan Institute of Medical Sciences Hassan Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banavase","family":"Channakeshavaiah Ravikumar","sequence":"additional","affiliation":[{"name":"Department of D.V.L Hassan Institute of Medical Sciences Hassan Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh Mahadevarahalli","family":"Rangegowda","sequence":"additional","affiliation":[{"name":"Department of D.V.L Hassan Institute of Medical Sciences Hassan Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)01479-8"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.04.063"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03197.x"},{"key":"e_1_2_5_5_1","first-page":"751","article-title":"The efficacy of three class I topical synthetic corticosteroids, fluocinonide 0.1% cream, clobetasol 0.05% cream and halobetasol 0.05% cream:a Scholtz\u2010Dumas bioassay comparison","volume":"8","author":"Lee CS","year":"2009","journal-title":"J. Drugs Dermatol."},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.77550"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630152607862"},{"key":"e_1_2_5_8_1","first-page":"888","article-title":"The use of methotrexate, alone or in combination with other therapies for the treatment of palmoplantar psoriasis","volume":"14","author":"Wald JM","year":"2015","journal-title":"J. Drugs Dermatol."},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12004"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1963.01590140120019"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1967.01610050005001"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1969.tb16033.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2340\/0001555566515519"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1971.04000210010003"},{"key":"e_1_2_5_15_1","first-page":"270","article-title":"Topical methotrexate therapy in palmoplantar psoriasis","volume":"65","author":"Ravikumar BC","year":"1999","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2001.01244.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/120347540100500403"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2004.tb00602.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02911.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.32709"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1972.01620120045009"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12481444"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06455.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(00)00599-8"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2003.08.011"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717540802035145"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-973X.93011"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.03062.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdvl.IJDVL_185_16"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01718.x"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.13228","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajd.13228","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.13228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T10:03:19Z","timestamp":1733738599000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.13228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,16]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/ajd.13228"],"URL":"https:\/\/doi.org\/10.1111\/ajd.13228","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,16]]},"assertion":[{"value":"2019-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}