{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:09:17Z","timestamp":1777648157642,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T00:00:00Z","timestamp":1577923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>The role of the pro\u2010inflammatory cytokine, interleukin (IL)\u201017 is being continuously explored in various autoimmune disorders. Studies have assessed the levels of IL\u201017 in vitiligo patients. This study aims to evaluate the IL\u201017 levels in vitiligo patients in comparison with the healthy controls by performing a meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review of the existing literature was performed in PubMed, Scopus and Cochrane databases by two authors independently. The data required to calculate the pooled effect size in the form of standardised mean difference (SMD) with the corresponding 95% confidence interval (CI) were extracted from the eligible studies. Separate analyses for active and stable vitiligo were also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 11 case\u2013control studies with 626 vitiligo patients and 475 healthy controls were included. Random\u2010effects meta\u2010analysis found significantly higher serum IL\u201017 levels in vitiligo patients compared with the healthy controls (SMD\u00a0=\u00a01.67, 95% CI 1.11 to 2.22, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The IL\u201017 levels were higher in both active (SMD\u00a0=\u00a01.31, 95% CI 0.76 to 1.86) and stable (SMD\u00a0=\u00a01.47, 95% CI 0.59 to 2.35) vitiligo patients compared with the healthy controls. The skin IL\u201017 levels were also significantly higher in vitiligo patients (SMD\u00a0=\u00a01.28, 95% CI 0.82 to 1.74). Heterogeneity in the baseline characteristics of the included studies was the major limitation of this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that vitiligo patients have significantly elevated IL\u201017 levels. Further examination of this association could have implications for the treatment of vitiligo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13233","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T14:52:05Z","timestamp":1577976725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Interleukin\u201017 level in patients with vitiligo: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-9199","authenticated-orcid":false,"given":"Prakash","family":"Acharya","sequence":"first","affiliation":[{"name":"Department of Dermatology College of Medical Sciences Bharatpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7831-8949","authenticated-orcid":false,"given":"Mahesh","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medical Sciences Bharatpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.11.061"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.32"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.01.004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.04.006"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03972.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12369"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.07.018"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2013.2023"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.05.005"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1690-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12667"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479925"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2016.12.014"},{"key":"e_1_2_6_15_1","first-page":"1","article-title":"Cytokine profile (IL\u20102, IL\u20106, IL\u201017, IL\u201022, and TNF\u2010a) in vitiligo\u2014New insight into pathogenesis of disease","volume":"00","author":"Sushama S","year":"2018","journal-title":"J Cosmet Dermatol"},{"key":"e_1_2_6_16_1","first-page":"408","article-title":"Changes in sICAM\u20101 and GM\u2010CSF levels in skin tissue fluid and expression of IL\u20106, IL\u201017 and TNF\u2010\u03b1 in blood of patients with vitiligo","volume":"17","author":"Yang X","year":"2019","journal-title":"Exp. 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