{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T03:18:40Z","timestamp":1761621520130,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81972560"],"award-info":[{"award-number":["No. 81972560"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The study examines the changes in dermoscopic features of actinic keratosis (AK) after photodynamic therapy, and delineates the association between AK dermoscopic and histopathological findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 21 patients (23 lesions) with pathologically confirmed actinic keratosis who received 5\u2010aminolaevulinic acid (ALA) photodynamic therapy (ALA\u2010PDT) were enrolled. The numbers of PDT treatments were: 1, <jats:italic>n<\/jats:italic>\u00a0=\u00a01; 2, <jats:italic>n<\/jats:italic>\u00a0=\u00a02; 3, <jats:italic>n<\/jats:italic>\u00a0=\u00a010; 4, <jats:italic>n<\/jats:italic>\u00a0=\u00a06; 5, <jats:italic>n<\/jats:italic>\u00a0=\u00a02; 6, <jats:italic>n<\/jats:italic>\u00a0=\u00a02). The dermoscopic features before and after the PDT were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were statistically significant decreases in the positive rates of dermoscopic features including scales (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), follicular plugs with whitish halo (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.013), and red pseudonetwork (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.022) among patients treated with ALA\u2010PDT. Dermoscopic feature was significantly associated with pathological grade (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Histopathological hyperkeratosis was significantly associated with dermoscopic red pseudonetwork (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.034) and wavy vessel (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005). Parakeratosis was associated with wavy vessels (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). For vascular hyperplasia in dermal papillae, the significant correlates included scales (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.011), follicular plugs with whitish halo (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.011), red pseudonetwork (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001); coiled vessels (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) and rosette sign (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004). Wavy vessels was the only feature correlating keratosis pilaris (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of the present study support dermoscopy as having potential to be useful for diagnosing and monitoring of actinic keratosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13289","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T05:31:11Z","timestamp":1589866271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessment of 5\u2010Aminolaevulinic Acid Photodynamic Therapy (ALA\u2010PDT) in Chinese patients with actinic keratosis: Correlation of dermoscopic features with histopathology"],"prefix":"10.1111","volume":"61","author":[{"given":"Qiuzi","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Dermatology Peking University Third Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5576-7944","authenticated-orcid":false,"given":"Weiwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University Third Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenting","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University Third Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center of Clinical Epidemiology Peking University Third Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University Third Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University Third Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University Third Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07860.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.103344"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1085-5629(99)80003-0"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.1.66"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630902887211"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12343"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2012.12.003"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000611"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp11X578142"},{"key":"e_1_2_5_11_1","first-page":"186","article-title":"Dermatoscopic and histopatological aspect of preneoplasia and skin cancers \u2010 study on 74 patients","volume":"41","author":"Stoica LE","year":"2015","journal-title":"Curr. 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