{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:16:36Z","timestamp":1769818596120,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T00:00:00Z","timestamp":1592092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Leiomyosarcoma of skin (LMS) can be sub\u2010classified on pathology appearances as Dermal or Subcutaneous. The aim of this study was to provide treatment recommendations for these uncommon tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of all patients with dermal and subcutaneous leiomyosarcoma managed at the Peter MacCallum Cancer Centre, Australia from January 2003 to December 2018 was performed. Eighty\u2010three patients were identified (64 dermal leiomyosarcoma, 19 subcutaneous leiomyosarcoma).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Subcutaneous leiomyosarcoma were larger (median size 14\u00a0mm dermal, 49\u00a0mm subcutaneous, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). No patient with a dermal leiomyosarcoma developed metastatic disease compared to 4 of the 19 subcutaneous leiomyosarcoma (5\u2010year overall survivals, 98% and 88%, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). The most common site of metastasis was to the lung. No difference in risk of local recurrence was apparent (5\u2010year recurrence\u2010free survivals were 85% and 78%, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.17). Adjuvant radiotherapy was used in 16 (25%) dermal leiomyosarcoma patients and 13 (68%) subcutaneous leiomyosarcoma patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Local recurrence was uncommon in both tumour subtypes when patients received definitive surgical excision (minimum histological margins of 10\u00a0mm as per institutional protocol) regardless of whether radiotherapy was used. The 5\u2010year local recurrence\u2010free survival for dermal leiomyosarcoma treated with radiotherapy was 93%\u00a0versus 83% without radiotherapy (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.7) and for subcutaneous leiomyosarcoma was 69% and 100%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dermal leiomyosarcoma have an excellent prognosis, particularly after definitive surgical excision with margins of at least 10\u00a0mm. Subcutaneous leiomyosarcoma has poorer outcomes and should be managed by wider excision and considered for adjuvant radiotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13307","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T05:21:11Z","timestamp":1592198471000},"page":"243-249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cutaneous leiomyosarcoma: dermal and subcutaneous"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9167-3168","authenticated-orcid":false,"given":"Gwyneth Natalie","family":"Wong","sequence":"first","affiliation":[{"name":"Division of Cancer Surgery Peter MacCallum Cancer Centre Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0659-8029","authenticated-orcid":false,"given":"Angela","family":"Webb","sequence":"additional","affiliation":[{"name":"Division of Cancer Surgery Peter MacCallum Cancer Centre Melbourne VIC Australia"},{"name":"Department of Cancer Surgery University of Melbourne Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3165-4694","authenticated-orcid":false,"given":"David","family":"Gyorki","sequence":"additional","affiliation":[{"name":"Division of Cancer Surgery Peter MacCallum Cancer Centre Melbourne VIC Australia"},{"name":"Department of Cancer Surgery University of Melbourne Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"McCormack","sequence":"additional","affiliation":[{"name":"Division of Cancer Surgery Peter MacCallum Cancer Centre Melbourne VIC Australia"},{"name":"Department of Cancer Surgery University of Melbourne Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Peter MacCallum Cancer Centre Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0987-2281","authenticated-orcid":false,"given":"Samuel Y.","family":"Ngan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Peter MacCallum Cancer Centre Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Slavin","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology St Vincent\u2019s Hospital Melbourne Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2496-8572","authenticated-orcid":false,"given":"Michael A.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Division of Cancer Surgery Peter MacCallum Cancer Centre Melbourne VIC Australia"},{"name":"Department of Cancer Surgery University of Melbourne Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2015.2681"},{"key":"e_1_2_5_3_1","first-page":"307","article-title":"Cutaneous and subcutaneous leiomyosarcoma. 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