{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:05:28Z","timestamp":1762376728020,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:00:00Z","timestamp":1589241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gluten sensitivity among psoriasis patients and its association with gender, age, disease duration and severity of psoriasis are under studied in Indians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine association among serum levels of anti\u2010tTG and anti\u2010gliadin antibodies and clinical features including gender, age, duration and severity of psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum levels of anti\u2010transglutaminase and anti\u2010gliadin antibodies were measured quantitatively in 80 (M:F 57:23) psoriasis patients aged 15 to 83\u00a0years and matched healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010five (56.3%) patients were aged \u226541years, duration of disease was &gt;5years in 43(53.8%) patients, and 22 (27.5%) patients had moderate\u2010to\u2010severe psoriasis. Two (2.5%) patients had arthritis and elevated serum anti\u2010gliadin antibody. Significantly more patients than controls had elevated serum anti\u2010gliadin antibody (67.5% vs. 2.5%) and anti\u2010transglutaminase antibody levels (62.5% vs. 0%). Two patients, each with mild and moderate\u2010to\u2010severe psoriasis, had highly elevated serum anti\u2010gliadin antibody and symptoms akin to coeliac disease. Except for a longer duration of psoriasis in patients with elevated anti\u2010gliadin antibodies, there was no statistically significant difference in gender, age, and severity of psoriasis when compared with patients having normal levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Significant elevation of serum anti\u2010transglutaminase and anti\u2010gliadin antibodies levels is noted in psoriasis patients reflecting a possible link. However, results need careful interpretation for any significance of gluten sensitivity in pathogenesis of psoriasis\/arthritis or as a stand\u2010alone risk factor for chronicity\/severity of psoriasis or whether gluten\u2010free diet will be ameliorating. Small number of subjects, cross\u2010sectional study design, lack of pathological\/endoscopic diagnosis and follow\u2010up are study limitations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13308","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T23:19:55Z","timestamp":1589325595000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The association of anti\u2010gliadin and anti\u2010transglutaminase antibodies and chronic plaque psoriasis in Indian patients: Preliminary results of a descriptive cross\u2010sectional study"],"prefix":"10.1111","volume":"61","author":[{"given":"Niharika","family":"Dhattarwal","sequence":"first","affiliation":[{"name":"Departments of Department of Dermatology, Venereology &amp; Leprosy Dr. R. P. Govt. 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