{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:32:18Z","timestamp":1781307138530,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objective<\/jats:title><jats:p>Melasma is a commonly acquired disorder of hyperpigmentation that often poses a therapeutic challenge for dermatologists. Recently, cysteamine cream has shown promising results compared to placebo. This study aims to determine the efficacy of cysteamine cream compared to hydroquinone cream in the treatment of melasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomised, double\u2010blinded, single\u2010centre trial was conducted in Victoria, Australia. 20 recruited participants were given either cysteamine cream or hydroquinone cream for 16\u00a0weeks. The primary outcome measure was a change in the modified Melasma Area and Severity Index (mMASI). Quality of life at baseline and week 16 as well as standard digital photography at each follow\u2010up visit was assessed as secondary outcome measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At week 16, 14 participants completed the study with 5 participants in the cysteamine group and 9 patients in the hydroquinone group. In the intention to treat analysis, there was a 1.52\u00a0\u00b1\u00a00.69 (21.3%) reduction in mMASI for the cysteamine group and a 2.96\u00a0\u00b1\u00a01.15 (32%) reduction in the hydroquinone group. The difference between groups was not statistically significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.3). Hydroquinone cream was generally better tolerated that cysteamine cream.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggests that topical cysteamine may have comparable efficacy to topical hydroquinone. Cysteamine thus provides a possible alternative to patients and clinicians who wish to avoid or rotate off topical hydroquinone. While side effects were more common for participants using cysteamine compared with hydroquinone, these were mild and reversible. Larger studies comparing cysteamine and hydroquinone are required to support these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13432","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T17:25:08Z","timestamp":1601227508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Evaluation of the efficacy of cysteamine cream compared to hydroquinone in the treatment of melasma: A randomised, double\u2010blinded trial"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6988-9555","authenticated-orcid":false,"given":"Jennifer","family":"Nguyen","sequence":"first","affiliation":[{"name":"Victorian Melanoma Service Alfred Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Remyn","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Dentistry and Health Sciences Melbourne University Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0671-244X","authenticated-orcid":false,"given":"In Young","family":"Chung","sequence":"additional","affiliation":[{"name":"The Royal Victorian Eye and Ear Hospital East Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4872-6340","authenticated-orcid":false,"given":"Anthony","family":"Honigman","sequence":"additional","affiliation":[{"name":"St Vincent\u2019s Hospital Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shima","family":"Gourani\u2010Tehrani","sequence":"additional","affiliation":[{"name":"Chroma Dermatology, Pigment and Skin of Colour Centre Wheelers Hill Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0324-728X","authenticated-orcid":false,"given":"Ilycia","family":"Wutami","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Dentistry and Health Sciences Melbourne University Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestine","family":"Wong","sequence":"additional","affiliation":[{"name":"Chroma Dermatology, Pigment and Skin of Colour Centre Wheelers Hill Victoria Australia"},{"name":"Department of Dermatology Monash Health Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eldho","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Chroma Dermatology, Pigment and Skin of Colour Centre Wheelers Hill Victoria Australia"},{"name":"Department of Dermatology and Department of Paediatrics Royal Children\u2019s Hospital &amp; Melbourne University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2007.04.006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630050517333"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12290"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.12.046"},{"key":"e_1_2_6_6_1","first-page":"1156","article-title":"Topical Treatments for Melasma: A Systematic Review of Randomized Controlled Trials","volume":"18","author":"Austin E","year":"2019","journal-title":"J. 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