{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T19:50:02Z","timestamp":1762026602605,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T00:00:00Z","timestamp":1600560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alopecia areata is a common non\u2010scarring hair loss disorder. It has been generally recognised as a loss of immune privilege leading to an autoimmune attack upon anagen hair follicles. Survivin is one of the apoptosis inhibitor proteins, responsible for apoptosis suppression and cell cycle regulation. Survivin expression has been demonstrated in the matrix and outer root sheath keratinocytes of anagen hair follicles. Survivin overexpression was shown in several autoimmune diseases, and it was postulated that it contributes to the survival of self\u2010reactive T and B cells. <jats:italic>P53<\/jats:italic> is a tumour suppressor gene that was suggested to repress autoimmunity via induction of T regulatory cells. Survivin gene expression is transcriptionally suppressed by wild\u2010type p53.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to investigate survivin and <jats:italic>p53<\/jats:italic> genes expression in alopecia areata patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The mRNA tissue expression of survivin and p53 was measured by quantitative real\u2010time polymerase chain reaction in lesional and non\u2010lesional punch scalp biopsies of 25 alopecia areata patients and 25 healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study showed higher mRNA expression of survivin in lesional biopsies compared to non\u2010lesional (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and control biopsies (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). In non\u2010lesional biopsies, the expression was significantly lower than in control biopsies (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The expression of p53 was lower in both lesional and non\u2010lesional biopsies relative to control biopsies. However, the difference was only significant in non\u2010lesional biopsies (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggested that survivin and <jats:italic>p53<\/jats:italic> genes expression was altered in patients with alopecia areata.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13433","type":"journal-article","created":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T11:03:05Z","timestamp":1600599785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Expression of survivin and <i>p53<\/i> genes in patients with alopecia areata: A case\u2013control study"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8144-0926","authenticated-orcid":false,"given":"Radwa El\u2010 Sayed Mahmoud","family":"Marie","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology 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