{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:04:03Z","timestamp":1771261443510,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>A randomised controlled trial was undertaken to compare the efficacy of topical <jats:italic>Calendula officinalis<\/jats:italic> (Calendula) versus standard of care (Sorbolene: 10% glycerine in cetomacragol cream) in reducing the prevalence of radiation\u2010induced dermatitis in women undergoing breast cancer radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 271 women were screened and 82 were randomised. The primary outcome was prevalence of acute radiation\u2010induced dermatitis (RTOG grade 2+) assessed at multiple skin sites. A chi\u2010squared test was conducted for the primary outcome with a worst\u2010case scenario imputation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The recruitment target (<jats:italic>n<\/jats:italic>\u00a0=\u00a0178) was not achieved. A total of <jats:italic>n<\/jats:italic>\u00a0=\u00a081 participants were analysed (<jats:italic>n<\/jats:italic>\u00a0=\u00a040 Calendula; <jats:italic>n<\/jats:italic>\u00a0=\u00a041 Sorbolene). There was no detectable difference in prevalence of radiation\u2010induced dermatitis grade 2+ between the Calendula (53%) and Sorbolene (62%) groups (primary analysis OR\u00a0=\u00a00.87, 95% CI: [0.36, 2.09], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.92; covariate adjusted complete case analysis OR 0.40, 95% CI: [0.13, 1.20], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.10).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This randomised controlled trial showed no difference between Calendula and standard of care (Sorbolene) for the prevention of radiation\u2010induced dermatitis. However, the study was underpowered (limited recruitment) for the primary comparison.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13434","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T12:50:21Z","timestamp":1600865421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Efficacy of topical <i>Calendula officinalis<\/i> on prevalence of radiation\u2010induced dermatitis: A randomised controlled trial"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6572-1683","authenticated-orcid":false,"given":"Shihab","family":"Siddiquee","sequence":"first","affiliation":[{"name":"Adelaide Medical School University of Adelaide Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret A","family":"McGee","sequence":"additional","affiliation":[{"name":"Freemasons Foundation Centre for Men\u2019s Health University of Adelaide Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D","family":"Vincent","sequence":"additional","affiliation":[{"name":"Freemasons Foundation Centre for Men\u2019s Health University of Adelaide Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Giles","sequence":"additional","affiliation":[{"name":"Department of Allied Health and Human Performance University of South Australia Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn","family":"Clothier","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Royal Adelaide Hospital Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Carruthers","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Royal Adelaide Hospital Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Penniment","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Royal Adelaide Hospital Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"299","article-title":"Radiotherapy and wound healing: principles, management and prospects (review)","volume":"26","author":"Gieringer M","year":"2011","journal-title":"Oncol. 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