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Studies have revealed reduction of erythema by oral tranexamic acid; however, there has been no direct comparison to placebo. This 24\u2010week randomised placebo\u2010controlled trial demonstrates oral tranexamic acid may improve erythema in melasma. This mechanism of action may be the reason for the success of tranexamic acid in complex and difficult to treat melasma.<\/jats:p>","DOI":"10.1111\/ajd.13482","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T19:24:22Z","timestamp":1604085862000},"page":"206-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of oral tranexamic acid on erythema index in patients with melasma"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6988-9555","authenticated-orcid":false,"given":"Jennifer","family":"Nguyen","sequence":"first","affiliation":[{"name":"Victorian Melanoma Service Alfred Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harini","family":"Rajgopal Bala","sequence":"additional","affiliation":[{"name":"Department of Dermatology Royal Melbourne Hospital Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7928-8753","authenticated-orcid":false,"given":"Angelique","family":"Ross","sequence":"additional","affiliation":[{"name":"Emergency Department Monash Health Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3115-3272","authenticated-orcid":false,"given":"Celestine C","family":"Wong","sequence":"additional","affiliation":[{"name":"Chroma Dermatology Pigment and Skin of Colour Centre Wheelers Hill Victoria Australia"},{"name":"Department of Dermatology Monash Health Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eldho","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9747-1882","authenticated-orcid":false,"given":"Michelle","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Chroma Dermatology Pigment and Skin of Colour Centre Wheelers Hill Victoria Australia"},{"name":"Department of Dermatology and Department of Paediatrics Royal Children\u2019s Hospital &amp; Melbourne University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12684"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/1683414","article-title":"Tranexamic Acid for Adults with Melasma. 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