{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:06:39Z","timestamp":1780340799414,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The question of whether solid malignancies (SMs) are associated with pyoderma gangrenosum (PG) remains to be conclusively answered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the risk of SM among patients with PG and the odds of PG after a diagnosis of SM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based retrospective cohort study was conducted to study the risk for SM in patients with PG (<jats:italic>n<\/jats:italic>\u00a0=\u00a0302) as compared with age\u2010, sex\u2010 and ethnicity\u2010matched control subjects (<jats:italic>n<\/jats:italic>\u00a0=\u00a01799). A case\u2013control design was used to estimate the odds of PG in those with a preexisting history of SM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of a preexisting SM was comparable in patients with PG and controls (7.5% vs. 8.8%, respectively; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.490). The odds of having PG following a diagnosis of a SM was not statistically increased (OR, 0.85; 95% CI, 0.53\u20131.36). The incidence of SM was 6.8 (95% CI, 3.5\u201312.2) and 7.9 (95% CI, 6.1\u201310.1) per 1000 person\u2010years among patients with PG and controls, respectively. Patients with PG were not more likely to develop SM as compared to controls (HR, 0.86; 95% CI, 0.44\u20131.69). Patients with a dual diagnosis of PG and SM were older and had more frequent comorbid conditions and increased mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SM is not associated with provoking PG, and patients with PG are not at an increased risk of developing SM. A thorough routine screening for SM in patients with new\u2010onset PG is an unnecessary approach based on the study findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13631","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T17:48:28Z","timestamp":1622656108000},"page":"336-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Is pyoderma gangrenosum associated with solid malignancies? 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