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We report 2 cases of treatment resistant nail psoriasis which showed marked improvement with the use of off\u2010label tildrakizumab. The dosing regimen utilised was consistent with that used to treat chronic plaque psoriasis, with 100\u00a0mg subcutaneously at Day 0 and Week 4, and maintenance dosing of 100\u00a0mg every 12\u00a0weeks thereafter. Significant improvement at 6 and 12\u00a0months, as per the modified Nail Psoriasis Severity Index (mNAPSI) and Dermatology Life Quality Index (DLQI), was seen. There have been no tildrakizumab related side effects observed to date. Tildrakizumab appears to be an effective option in managing treatment resistant nail psoriasis.<\/jats:p>","DOI":"10.1111\/ajd.13642","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T10:27:20Z","timestamp":1623407240000},"page":"390-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Successful management of treatment resistant nail psoriasis with tildrakizumab"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7171-6589","authenticated-orcid":false,"given":"Kate","family":"Simpson","sequence":"first","affiliation":[{"name":"Dermatology Department The Royal Melbourne Hospital Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0848-4524","authenticated-orcid":false,"given":"Zhi Mei","family":"Low","sequence":"additional","affiliation":[{"name":"Dermatology Department The Royal Melbourne Hospital Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Howard","sequence":"additional","affiliation":[{"name":"Dermatology Department The Royal Melbourne Hospital Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6372-8048","authenticated-orcid":false,"given":"Johannes S","family":"Kern","sequence":"additional","affiliation":[{"name":"Dermatology Department The Royal Melbourne Hospital Parkville Victoria Australia"},{"name":"Faculty of Medicine, Dentistry and Health Sciences Univeristy of Melbourne Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/11597000-000000000-00000"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/ddg.12054","article-title":"Nail psoriasis \u2010 a treatment challenge","volume":"11","author":"Radtke MA","year":"2013","journal-title":"J. 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