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Demographic and clinical data were collected from relevant English articles published from January 2000 to December 2020. Complete resolution was observed in 100% of infants younger than two months treated with permethrin, and 87.6% of infants aged 12\u00a0months or less and\/or children weighing under 15\u00a0kg treated with ivermectin. Adverse effects from permethrin use were limited to local eczematous reactions. Adverse effects from ivermectin use included mildly elevated creatine kinase levels, eczema flare\u2010ups, diarrhoea, vomiting, irritability, pruritus and pustular skin reactions. Overall, both permethrin and ivermectin appear to have an acceptable safety profile in infants. Permethrin is highly effective as a first\u2010line therapy for scabies in infants younger than two months. Ivermectin use is recommended when authorised topical treatment has failed, in crusted scabies, in cases where compliance with topical agents may be problematic, and in infants with severely inflamed or broken skin where prescription of topical therapies would likely cause cutaneous and systemic toxicity. Additional high\u2010quality studies are needed to guide best practice in the management of infantile scabies.<\/jats:p>","DOI":"10.1111\/ajd.13654","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T08:50:55Z","timestamp":1624956655000},"page":"267-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A narrative review of the roles of topical permethrin and oral ivermectin in the management of infantile scabies"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8516-9408","authenticated-orcid":false,"given":"Yolanka","family":"Lobo","sequence":"first","affiliation":[{"name":"Department of Dermatology Mater Misericordiae Health Services Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Wheller","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mater Misericordiae Health Services Brisbane Queensland Australia"},{"name":"Department of Dermatology Queensland Children\u2019s Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.073825"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1994.tb00600.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30483-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058231"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMicm030276"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/2249-4847.144760"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13130"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70654-5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68772-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004151"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000495290"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2007.tb01059.x"},{"key":"e_1_2_6_14_1","first-page":"264","article-title":"Scabies: a clinical update","volume":"46","author":"Hardy M","year":"2017","journal-title":"Aust. 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