{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:35:28Z","timestamp":1747182928575,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Emerging evidence supports a strong association between the skin and the gut. The association between seborrheic dermatitis (SD) and peptic ulcer disease (PUD) was largely unknown. This study aimed to investigate the association of SD and PUD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This nationwide population\u2010based cohort study was conducted using the Taiwan's National Health Insurance Research Database. A total of 19\u2009445 participants was recruited. Each patient with a diagnosis of incident SD was matched to four patients without SD using propensity scores based on age, gender, index year, insurance amount, urbanisation level, Charlson comorbidity index (CCI), the presence of comorbidities and medication use. The primary endpoint was the development of incident PUD. Hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for PUD occurrence in relation to the presence of SD were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, patients with SD had a significantly higher risk for incident PUD than those without SD in both univariable (crude HR\u2009=\u20091.60, 95% CI 1.38\u20131.86, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and multivariable (adjusted HR\u2009=\u20091.58, 95% CI 1.36\u20131.83, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) Cox proportional hazard regression models. Kaplan\u2013Meier analysis indicated that the cumulative incidence of PUD was consistently higher in individuals with SD than those without SD (log\u2010rank test, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). A higher risk of PUD was also found in individuals with SD than those without SD in all stratified analyses by age, gender, CCI and follow\u2010up time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with SD may have a higher risk for incident PUD. Further studies are warranted to validate our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13680","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T19:12:15Z","timestamp":1628536335000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Seborrheic dermatitis and risk of incident peptic ulcer disease: A nationwide population\u2010based cohort study"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5761-8114","authenticated-orcid":false,"given":"Tai\u2010Li","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Medical Education Medical Administration Office Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei\u2010Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"Management Office for Health Data China Medical University Hospital Taichung Taiwan"},{"name":"College of Medicine China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen\u2010Hung","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Research Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Shuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung\u2010Y","family":"Hsu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Science China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3324-0962","authenticated-orcid":false,"given":"Ching\u2010Hui","family":"Loh","sequence":"additional","affiliation":[{"name":"School of Medicine Tzu Chi University Hualien Taiwan"},{"name":"Center for Aging and Health Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.13188\/2373\u20101044.1000019"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17826"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1315"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18088"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41435\u2010021\u201000133\u20109"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.3631"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01624-x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.37321\/dermatology.2019.1\u20102\u201005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3920\/BM2016.0144"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-017-9999-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32404-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.3540"},{"volume-title":"Longitudinal Health Insurance Databases","author":"National Health Research Institutes","key":"e_1_2_8_15_1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2018.01.003"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/ds.ds_30_19"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002787"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85598-4"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15050912"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12310"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15908"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2015.2706"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-013-0019-7"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.07.027"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13726"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094529"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15951"},{"key":"e_1_2_8_29_1","first-page":"253","article-title":"Impact of the microbiota and gastric disease development by Helicobacter pylori","volume":"400","author":"Alarc\u00f3n T","year":"2017","journal-title":"Curr. 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