{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T02:35:07Z","timestamp":1784342107628,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Limited studies exist on the factors associated with a complete cure of onychomycosis in older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the age and factors associated with a complete cure among older adults diagnosed with toenail onychomycosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was conducted of 95 older adult patients (aged \u2265 60\u2009years) diagnosed with toenail onychomycosis between January 2016 and December 2017. Demographic data, mycological findings, treatments and durations to a complete cure were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The complete cure rates of the patients aged &lt; 70\u2009years and \u226570\u2009years were 67.4% and 44.9%, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.027). Patients aged \u2265 70\u2009years were significantly higher in male gender, had higher history of smoking, peripheral arterial disease, impaired renal function, antihypertensive drug and amorolfine nail lacquer usage, and polypharmacy. A multivariate analysis revealed that being aged \u226570\u2009years and having a nail thickness &gt;2\u2009mm were associated with failure to achieve a complete cure. The median times to a complete cure for older adults aged &lt;70\u2009years and \u226570\u2009years were 20\u2009months and 47\u2009months, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An age \u2265 70\u2009years was related to a lower cure rate and delays in achieving a complete cure. A nail thickness &gt; 2\u2009mm was a poor prognostic factor for a complete cure. Moreover, very old adults were more likely to suffer side effects arising from the use of systemic antifungal medications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13686","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T12:44:29Z","timestamp":1629117869000},"page":"74-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Onychomycosis in older adults: The age and associated factors affecting the complete cure rate"],"prefix":"10.1111","volume":"63","author":[{"given":"Sumanas","family":"Bunyaratavej","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varalak","family":"Srinonprasert","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine Department of Medicine Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rungsima","family":"Kiratiwongwan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supisara","family":"Wongdama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8430-376X","authenticated-orcid":false,"given":"Charussri","family":"Leeyaphan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12768"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.110874"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpm.2016.02.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475416653734"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.7547\/0003-0538-104.4.330"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.05.041"},{"key":"e_1_2_8_8_1","first-page":"38","article-title":"Risk factors and comorbidities for onychomycosis: implications for treatment with topical therapy","volume":"8","author":"Elewski BE","year":"2015","journal-title":"J. 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