{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:57:48Z","timestamp":1783025868402,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adult female acne (AFA) may be different from adolescent acne, and may be a sign of polycystic ovary syndrome (PCOS). The objective of the study was to investigate the clinical characteristics of AFA, and the factors significantly associated with PCOS in AFA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>AFA patients aged 25\u2009years or older were enrolled. History taking and dermatologic examinations were performed by dermatologists. PCOS was diagnosed by gynaecologists. Perimenopausal acne (aged 45\u2009years or older) and the Dermatology Life Quality Index (DLQI) were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 208 patients, mean age was 31.8\u2009\u00b1\u20097.1\u2009years and 47.1%, 26.9%, and 26% had persistent, late\u2010onset, and recurrent acne, respectively. The common aggravating factors included pre\u2010menstruation (72.6%) and stress (53.8%). Recurrent acne was significantly aggravated by cosmetic products. Higher body mass index (BMI) was positively correlated with acne severity. Acne lesions were predominately located on both cheeks (87.0%) and at the perioral area (81.7%). PCOS was identified in 48.1%. Younger age (\u226525 to &lt;33\u2009years), premenstrual flare, and irregular menstruation, but not hirsutism or androgenetic alopecia, were associated with PCOS in univariate and multivariate analysis. Perimenopausal acne was identified in 6.7%. The total mean DLQI score was 8.0\u2009\u00b1\u20095.4 (range from 0 to 23).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Persistent acne with moderate severity was common in AFA patients and higher BMI was associated with acne severity. PCOS should be screened in AFA patients with younger age, premenstrual flare, and irregular menstruation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13700","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T13:15:18Z","timestamp":1629724518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Adult female acne: Clinical characteristics and factors significantly associated with polycystic ovary syndrome"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0928-5650","authenticated-orcid":false,"given":"Pattriya","family":"Chanyachailert","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6625-6445","authenticated-orcid":false,"given":"Leena","family":"Chularojanamontri","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7860-3181","authenticated-orcid":false,"given":"Panicha","family":"Chantrapanichkul","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0599-4062","authenticated-orcid":false,"given":"Papapit","family":"Tuchinda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9380-7580","authenticated-orcid":false,"given":"Thanyarat","family":"Wongwananuruk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phatcharee","family":"Sardod","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7618-821X","authenticated-orcid":false,"given":"Kanokvalai","family":"Kulthanan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2001.00357.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)80056-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04214.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.11.021"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12757"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2010.2722"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S137794"},{"key":"e_1_2_8_9_1","first-page":"37","article-title":"Emerging issues in adult female acne","volume":"10","author":"Zeichner JA","year":"2017","journal-title":"J. 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