{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:19:41Z","timestamp":1773188381857,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011960","name":"Debra International","doi-asserted-by":"publisher","award":["2500 Euros"],"award-info":[{"award-number":["2500 Euros"]}],"id":[{"id":"10.13039\/501100011960","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To establish the epidemiological, clinical, pathological and genetic characteristics of epidermolysis bullosa (EB) in New Zealand (NZ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were recruited through the Dystrophic Epidermolysis Bullosa Research Association of New Zealand (DEBRA NZ). Dedicated EB nurse medical records, Genetic Health Service NZ (GHSNZ) records and, where available, public hospital records were manually reviewed for relevant clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010two participants took part in the study (56% participation rate). Forty\u2010nine (53%) participants had EB simplex (EBS), 40 (43%) had dystrophic EB (DEB), and 3 (3%) had junctional EB (JEB). Point prevalence for EB of all types was 19.5 per million, and 10.4, 8.6 and 0.9 per million for EBS, DEB and JEB, respectively. Thirty\u2010four participants had intermediate or severe EB. There were 29 paediatric cases and almost even numbers of males and females. Compared to NZ European and M\u0101ori, prevalence rates were lower for Pacific and Asian people and higher in the Middle Eastern\/Latin American\/African population. Eight out of 14 skin biopsy results were informative, and 14 of 15 genetic test results were informative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>New Zealand has similar prevalence rates of EB compared with other national cohorts. This is likely to be an underestimate due to methodological limitations. Recent advancements in genomic testing have resulted in an improved diagnostic rate in our population. Further research into ethnic differences in prevalence, and exploring the characteristics of lethal forms of EB, is warranted. A dynamic registry may be helpful for the EB community in NZ.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13762","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T19:38:43Z","timestamp":1639510723000},"page":"62-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Epidemiological, clinical, pathological and genetic characteristics of epidermolysis bullosa in New Zealand"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5378-6746","authenticated-orcid":false,"given":"Russell","family":"Gear","sequence":"first","affiliation":[{"name":"Genetics Health Service NZ Central Hub Wellington Hospital Capital and Coast District Health Board Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Poke","sequence":"additional","affiliation":[{"name":"Genetics Health Service NZ Central Hub Wellington Hospital Capital and Coast District Health Board Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Neas","sequence":"additional","affiliation":[{"name":"Genetics Health Service NZ Central Hub Wellington Hospital Capital and Coast District Health Board Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqui","family":"Finnigan","sequence":"additional","affiliation":[{"name":"Dystrophic Epidermolysis Bullosa Research Association of New Zealand Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Cassidy","sequence":"additional","affiliation":[{"name":"Dystrophic Epidermolysis Bullosa Research Association of New Zealand Wellington New Zealand"},{"name":"Child Health Service Canterbury District Health Board Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deanna","family":"Forsyth","sequence":"additional","affiliation":[{"name":"Dystrophic Epidermolysis Bullosa Research Association of New Zealand Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo","family":"Blishen","sequence":"additional","affiliation":[{"name":"Dystrophic Epidermolysis Bullosa Research Association of New Zealand Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Purvis","sequence":"additional","affiliation":[{"name":"Dermatology Department Starship Hospital Auckland District Health Board Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.01.903"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18921"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18128"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1962.156"},{"key":"e_1_2_9_6_1","volume-title":"Epidermolysis Bullosa: Clinical, Epidemiologic, and Laboratory Advances, and the Findings of the National Epidermolysis Bullosa Registry","author":"Fine JD","year":"1999"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17012"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.2473"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2013.03.006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102133.1997.d01\u20101235.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","unstructured":"InabaY KurosawaM HashimotoIet\u00a0al.Epidemiology of epidermolysis bullosa and generalized pustular psoriasis. 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Ministry of Welfare and Health of Japan 1995;19\u201336.https:\/\/doi.org\/10.1016\/j.det.2010.02.010.","DOI":"10.1016\/j.det.2010.02.010"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.109"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14099"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101747.2001.01279\u201011.x"},{"key":"e_1_2_9_15_1","volume-title":"2018 National Census Data","author":"Statistics New Zealand","year":"2018"},{"key":"e_1_2_9_16_1","volume-title":"HISO 10001: 2017 Ethnicity Data Protocols","author":"Ministry of Health","year":"2017"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S232547"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010020\u201001443\u20103"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17648"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.13762","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajd.13762","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.13762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T10:03:43Z","timestamp":1733738623000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.13762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,14]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/ajd.13762"],"URL":"https:\/\/doi.org\/10.1111\/ajd.13762","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,14]]},"assertion":[{"value":"2021-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}