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The current international consensus is that the use of intravenous CD20 inhibitors should be first\u2010line in the management of moderate\u2010to\u2010severe cases of pemphigus, however Australia is yet to adopt this. Systemic corticosteroids, combined with conventional corticosteroid\u2010sparing immunosuppressive agents such as azathioprine, mycophenolate mofetil, cyclosporin and methotrexate is still recommended as first\u2010line therapy in Australia despite overwhelming evidence that combining rituximab with a rapid corticosteroid tapering regime is more effective in the treatment of moderate\u2010to\u2010severe pemphigus, and leads to fewer severe adverse effects. We propose a therapeutic approach that echoes the international consensus and recommend that rituximab, an anti\u2010CD20 monoclonal antibody, be listed in the formularies of Australian Public Hospitals and on the Pharmaceutical Benefits Scheme\u00a0for use in moderate to severe pemphigus.<\/jats:p>","DOI":"10.1111\/ajd.13804","type":"journal-article","created":{"date-parts":[[2022,2,20]],"date-time":"2022-02-20T17:32:06Z","timestamp":1645378326000},"page":"190-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Treatment of pemphigus in Australia: Aligning current practises with global recommendations"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7840-8055","authenticated-orcid":false,"given":"Erin","family":"Somerville","sequence":"first","affiliation":[{"name":"Sir Charles Gairdner Hospital  Nedlands WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Gebauer","sequence":"additional","affiliation":[{"name":"University of Western Australia  Crawley WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4307-0837","authenticated-orcid":false,"given":"Andrew","family":"Mclean\u2010Tooke","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Sir Charles Gairdner Hospital  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)30070\u20103"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18482"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14546"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdvl.IJDVL_848_17"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01418"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.02.021"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16752"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.11.005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2020.1672539"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15930"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14633"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","unstructured":"HertlM JedlickovaH KarpatiS et\u00a0al.Pemphigus. 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