{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:24:40Z","timestamp":1779171880643,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 107\u20102314\u2010B\u2010075\u2010032\u2010MY3\u20102"],"award-info":[{"award-number":["MOST 107\u20102314\u2010B\u2010075\u2010032\u2010MY3\u20102"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MY3\u20102"],"award-info":[{"award-number":["MY3\u20102"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alopecia areata (AA) and irritable bowel syndrome (IBS) are two distinct diseases that share a similar pathophysiology; however, the relationship between these two diseases is unknown. This study aimed to investigate the bidirectional relationship between AA and IBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were recruited from the National Health Insurance Research Database in Taiwan. We included 5446 patients with AA and 21\u2009784 matched controls to assess the risk of IBS, and 56\u2009429 patients with IBS and 225\u2009716 matched controls to assess the risk of AA. The Cox proportional\u2010hazards regression model was used to calculate the adjusted hazard ratio (aHR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjustment for potential confounders, patients with AA had an aHR of 5.20 [95% confidence interval (CI) 3.97\u20136.82] for IBS in comparison with the controls. Furthermore, compared with the controls, IBS patients had an aHR of 5.38 (95% CI 3.95\u20137.34) for AA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AA is bidirectionally associated with IBS. Further investigation is needed to elucidate the shared pathogenesis underlying these two diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13809","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T17:55:20Z","timestamp":1645638920000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bidirectional association between alopecia areata and irritable bowel syndrome: A nationwide population\u2010based cohort study"],"prefix":"10.1111","volume":"63","author":[{"given":"Ying\u2010Xiu","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying\u2010Hsuan","family":"Tai","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang Ming Chiao 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