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One patient showed modest clinical improvement with no significant improvement in quality\u2010of\u2010life measures. The second patient showed a significant improvement in both clinical and quality\u2010of\u2010life measures. Both patients achieved optimal control with a maintenance dosing of 40\u2009mg subcutaneously weekly. Adalimumab may be a treatment option for recalcitrant VLS; however, clinical trials are required to confirm efficacy for this indication.<\/jats:p>","DOI":"10.1111\/ajd.13814","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T12:06:30Z","timestamp":1646827590000},"page":"248-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Management of severe vulval lichen sclerosus with adalimumab"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4043-1281","authenticated-orcid":false,"given":"Nicholas","family":"Manuelpillai","sequence":"first","affiliation":[{"name":"Skin Health Institute  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Saunders","sequence":"additional","affiliation":[{"name":"Department of Dermatology, St Vincent's Hospital  Melbourne Australia"},{"name":"Vulvar Clinic The Royal Women's Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1782-9945","authenticated-orcid":false,"given":"Emma","family":"Veysey","sequence":"additional","affiliation":[{"name":"Department of Dermatology, St Vincent's Hospital  Melbourne Australia"},{"name":"Vulvar Clinic The Royal Women's Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"950","article-title":"Vulvar lichen sclerosus from pathophysiology to therapeutic approaches: evidence and prospects","volume":"9","author":"Corazza M","year":"2021","journal-title":"Biomedicine"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.34613"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13594"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13235"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14212"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamadermatol.39"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.13814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajd.13814","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.13814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T12:34:20Z","timestamp":1692534860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.13814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,9]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/ajd.13814"],"URL":"https:\/\/doi.org\/10.1111\/ajd.13814","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,9]]},"assertion":[{"value":"2021-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}