{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:35:38Z","timestamp":1747182938345,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about mucocutaneous involvement in critically ill patients with the multisystem inflammatory syndrome in children (MIS\u2010C). The aim of our study was to describe the localisation and variety of rash and to investigate whether presenting with rash at admission alters the clinical course of MIS\u2010C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, observational cohort study was conducted amongst children under 18\u2009years of age who were admitted to our paediatric intensive care unit (PICU) between May 2020 and May 2021 with a possible diagnosis of MIS\u2010C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 33 children with MIS\u2010C, 21 boys (64%), with a median age of 9.4\u2009years (3.4\u201311.5) were enrolled. Twenty\u2010four children presented with mucocutaneous symptoms (72%). Age, male gender, PICU length of stay, presenting symptoms, inotrope requirement, the existence of myocarditis or respiratory failure were higher but not significantly different in patients with rash compared to those without rash (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). The median duration of symptoms before admission and presence of cervical lymphadenopathy were significantly higher in patients than those without rash (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Children with a rash had a significantly higher neutrophil count, CRP, procalcitonin, troponin levels and lower lymphocyte counts and albumin levels than those without rash (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Twelve children with rash (50%) had symmetrical intertriginous distribution. Two children had erythematous lesions on the areola and the surroundings.<\/jats:p><jats:p>In conclusion, intertriginous involvement, periareolar erythema and other mucocutaneous manifestations might be the first alarming symptoms of moderate to severe MIS\u2010C. Therefore, close monitoring with a multidisciplinary approach should be considered for these patients to assess potential disease progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13819","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T16:54:50Z","timestamp":1647363290000},"page":"228-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["New dermatological findings of <scp>MIS\u2010C<\/scp>: Can mucocutaneous involvement be associated with Severe Disease Course?"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8273-2226","authenticated-orcid":false,"given":"Nihal","family":"Ak\u00e7ay","sequence":"first","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, Bak\u0131rkoy Dr Sadi Konuk Research and Training Hospital University of Health Sciences  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3847-0695","authenticated-orcid":false,"given":"Zeynep","family":"Topkarc\u0131","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bakirkoy Dr Sadi Konuk Research and Training Hospital University of Health Sciences  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3839-4722","authenticated-orcid":false,"given":"Mehmet Emin","family":"Menento\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, Bak\u0131rkoy Dr Sadi Konuk Research and Training Hospital University of Health Sciences  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2731-4723","authenticated-orcid":false,"given":"Mustafa","family":"O\u011fur","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, Bak\u0131rkoy Dr Sadi Konuk Research and Training Hospital University of Health Sciences  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3757-912X","authenticated-orcid":false,"given":"Ay\u015fe \u0130rem","family":"Sofuo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, Bak\u0131rkoy Dr Sadi Konuk Research and Training Hospital University of Health Sciences  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3881-6980","authenticated-orcid":false,"given":"K\u00fcbra","family":"Boyda\u011f G\u00fcven\u00e7","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, Bak\u0131rkoy Dr Sadi Konuk Research and Training Hospital University of Health Sciences  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1521-7793","authenticated-orcid":false,"given":"Canan","family":"Baydemir","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Medicine Kocaeli University  Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8330-2877","authenticated-orcid":false,"given":"Esra","family":"\u015eevketo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, Bak\u0131rkoy Dr Sadi Konuk Research and Training Hospital University of Health Sciences  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization (WHO)Coronavirus disease (COVID\u201019) Situation Report 2020\u2013104[Internet]. Available athttps:\/\/covid19.who.int\/"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002599"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.10.060"},{"key":"e_1_2_7_5_1","unstructured":"Center for Disease Control and Prevention: Multisystem Inflammatory Syndrome in Children (MIS\u2010C)[Internet]. [cited 2021 April 2)https:\/\/www.cdc.gov\/mis\u2010c\/hcp\/index.html"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.4779"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.23736\/S2724\u20105276.21.06327\u20108"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.03.083"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2010.06.023"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12154"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1988.01670120021004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14558"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.13819","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajd.13819","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.13819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T12:32:14Z","timestamp":1692534734000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.13819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,15]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/ajd.13819"],"URL":"https:\/\/doi.org\/10.1111\/ajd.13819","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"type":"print","value":"0004-8380"},{"type":"electronic","value":"1440-0960"}],"subject":[],"published":{"date-parts":[[2022,3,15]]},"assertion":[{"value":"2021-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}