{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T04:44:11Z","timestamp":1769316251959,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T00:00:00Z","timestamp":1650067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A 25\u2010year\u2010old male patient presented with palmoplantar keratoderma, dystrophic nails, severe plantar pain and oral leukokeratosis since birth. On genetic analysis, a heterozygous KRT6A gene missense mutation (c.1381G\u2009&gt;\u2009A, p.Glu461Lys in exon 7) was identified by next\u2010generation sequencing technology, consistent with pachyonychia congenita 6a. Oral simvastatin 40\u2009mg was started once daily, and after 16\u2009weeks of therapy, excellent improvement was noted in palmoplantar keratoderma and plantar pain. The maximum thickness of his foot callosity reduced by 4\u2009mm on ultrasonography, and the Dermatology Life Quality Index score dropped significantly by eight points. These benefits may be attributed to inhibition of KRT6A gene expression, modulation of autophagy and mitophagy and Keap1\u2010Nrf2 signalling activation; the latter two mechanisms of statins previously undiscussed in the context of pachyonychia congenita. Simvastatin and other statins are pathogenesis\u2010targeted, disease\u2010modifying therapy in pachyonychia congenita, therefore qualifying as a promising treatment avenue and warranting further clinical trials.<\/jats:p>","DOI":"10.1111\/ajd.13835","type":"journal-article","created":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T16:39:48Z","timestamp":1650127188000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Scrutinising the role of simvastatin in a patient of Pachyonychia Congenita with <scp>KRT6A<\/scp> gene mutation"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7369-0776","authenticated-orcid":false,"given":"Shruti","family":"Sharma","sequence":"first","affiliation":[{"name":"Pt BD Sharma Postgraduate Institute of Medical Sciences  Rohtak India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surabhi","family":"Dayal","sequence":"additional","affiliation":[{"name":"Pt BD Sharma Postgraduate Institute of Medical Sciences  Rohtak India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Pt BD Sharma Postgraduate Institute of Medical Sciences  Rohtak India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varsha","family":"Gowda V.M","sequence":"additional","affiliation":[{"name":"Pt BD Sharma Postgraduate Institute of Medical Sciences  Rohtak India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupinder","family":"Kaur","sequence":"additional","affiliation":[{"name":"Pt BD Sharma Postgraduate Institute of Medical Sciences  Rohtak India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18794"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12098"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18033"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13686"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.273"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.41"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17276"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18254"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29227"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2013.2126"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5416"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17880"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-008-0393-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.117.014753"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.13835","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajd.13835","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.13835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T12:34:24Z","timestamp":1692534864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.13835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,16]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/ajd.13835"],"URL":"https:\/\/doi.org\/10.1111\/ajd.13835","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,16]]},"assertion":[{"value":"2022-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}