{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:45:59Z","timestamp":1762508759970,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Between 20% and 40% of women with vulvovaginal lichen planus (VLP) fail to respond to first\u2010line ultra\u2010potent topical corticosteroid treatment and require systemic immunosuppression to control disease. No data exist regarding risk factors for patients with severe VLP requiring systemic immunosuppression. We aimed to identify clinical features that predict women with VLP who are at risk of severe, recalcitrant disease requiring eventual escalation to systemic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A chart review was performed on a cohort of 122 adult women with VLP followed prospectively for 15\u2009years by the same clinician in a private dermatology practice in Australia between 1 January 2004 and 1 October 2021. Uni\u2010 and multivariable binary logistical regression analyses were performed to identify clinical features distinguishing women eventually requiring systemic treatment of VLP against those whose VLP was controlled with topical corticosteroids alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age at diagnosis of VLP was 61\u2009years, with 35 women (28.7%) requiring systemic treatment of VLP. A multivariable regression model utilising \u2018Age at Diagnosis\u2019 (adjusted OR\u00a0=\u00a00.97, 95% CI 0.94\u20130.99), \u2018Non\u2010Caucasian Ethnicity\u2019 (adjusted OR\u00a0=\u00a010.3, 95% CI 2.27\u201373.9) and \u2018Vulvar Pruritus\u2019 (adjusted OR\u00a0=\u00a02.69, 95% CI 1.11\u20136.86) demonstrated moderate predictive capacity, with specificity and sensitivity for predicting whether a patient will require systemic treatment for VLP of 95.3% and 40.5%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings may indicate women with VLP who are younger, of non\u2010Caucasian ethnicity, and presenting with vulval pruritus are the highest risk of severe disease requiring systemic immunosuppressive treatment and may benefit most from earlier initiation of systemic treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13851","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T19:14:58Z","timestamp":1651518898000},"page":"335-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identifying predictors of systemic immunosuppressive treatment of vulvovaginal lichen planus: A retrospective cohort study of 122 women"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2840-5256","authenticated-orcid":false,"given":"Ashod","family":"Kherlopian","sequence":"first","affiliation":[{"name":"Department of Dermatology, Dermatology Research Office Royal North Shore Hospital  St Leonards New\u00a0South Wales 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