{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:35:41Z","timestamp":1747182941921,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epidemiological evidence regarding the course and activity patterns of hidradenitis suppurativa (HS) is yet to be delineated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify activity patterns of HS throughout the time axis and to outline predictors of recalcitrant disease course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based retrospective cohort study was performed to follow patients with HS (<jats:italic>n<\/jats:italic>\u00a0=\u00a04417) throughout the initial 10\u2009years following their diagnosis. The disease was considered active in a certain month if one of the following criteria was fulfilled: (i) purchase of an HS\u2010related drug, (ii) admission to a dermatological ward and (iii) referral to a dermatological consultation in an emergency room. Patients with a recalcitrant disease were defined as those with \u22655\u2009years of follow\u2010up with \u22656 \u2018active months\u2019 each. Patients with an indolent course were defined as those experiencing \u22659\u2009years of follow\u2010up with \u22641 \u2018active months\u2019 each.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average (SD) number of months in which patients had an active disease was 1.37 (1.28) months per year. While 98 (2.2%) patients pursued a recalcitrant course, 1390 (31.5%) went through an indolent disease course. Older age (\u226538\u2009years; adjusted OR, 6.17; 95% CI, 3.33\u201311.43), Arab ethnicity (adjusted OR, 2.04; 95% CI, 1.20\u20133.48), low socioeconomic status (adjusted OR, 1.64; 95% CI, 1.03\u20132.60), obesity (adjusted OR, 3.47; 95% CI, 2.25\u20135.34) and smoking (adjusted OR, 2.65; 95% CI, 1.57\u20134.47) were found to independently predict recalcitrant course of HS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mild course is more frequently encountered than severe course among Israeli patients with HS. Modifiable risk factors of recalcitrant course should be carefully addressed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13854","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T06:43:25Z","timestamp":1651733005000},"page":"321-327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hidradenitis suppurativa: Evaluating activity patterns and predictors of recalcitrant course\u2013A population\u2010based study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8071-289X","authenticated-orcid":false,"given":"Shani","family":"Fisher","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Department Emek Medical Center  Afula Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilya","family":"Kagan","sequence":"additional","affiliation":[{"name":"Nursing Department Ashkelon Academic College  Ashkelon Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilach","family":"Zoller","sequence":"additional","affiliation":[{"name":"Clalit Health Services Tel\u2010Aviv and Haifa  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnon D.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Clalit Health Services Tel\u2010Aviv and Haifa  Tel Aviv Israel"},{"name":"Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9971-9151","authenticated-orcid":false,"given":"Khalaf","family":"Kridin","sequence":"additional","affiliation":[{"name":"Unit of Dermatology and Skin Research Laboratory Baruch Padeh Medical Center  Poriya Israel"},{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.16691"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2015.08.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/BJD.18093"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14075"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.061"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109681(87)90171\u20108"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.2012"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1057\/JT.2009.5\/TABLES\/2"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010019\u201002025\u20105"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2009.09198.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508528"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327928"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15939"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.043"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.04.006"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13090"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13777"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20101800"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.1677"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475419874412"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15579"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05485"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.soc.012809.102529"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAD.2016.04.067"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMADERMATOL.2018.2117"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13951"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA2035389"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2021.01.007"}],"container-title":["Australasian 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