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It is characterized by symmetrical erythema involving the gluteal and\/or inguinal area in association with one other intertriginous area in the absence of systemic involvement. It typically develops a few hours to days after drug exposure. The diagnosis is based on clinical presentation and drug history. The treatment consists mainly of withdrawal of the causative agent; corticosteroids (topical or systemic) are prescribed to accelerate the resolution. We present three cases that appeared after proton\u2010pump inhibitors (PPIs) intake.<\/jats:p>","DOI":"10.1111\/ajd.13905","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T16:01:26Z","timestamp":1658764886000},"page":"509-512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Three cases of symmetrical drug\u2010related intertriginous and flexural exanthema (SDRIFE) induced by proton\u2010pump inhibitors"],"prefix":"10.1111","volume":"63","author":[{"given":"Cristina B.","family":"Spigariolo","sequence":"first","affiliation":[{"name":"Unit of Dermatology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7188-7310","authenticated-orcid":false,"given":"Francesca","family":"Barei","sequence":"additional","affiliation":[{"name":"Unit of Dermatology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9449-849X","authenticated-orcid":false,"given":"Carlo A.","family":"Maronese","sequence":"additional","affiliation":[{"name":"Unit of Dermatology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Barberi","sequence":"additional","affiliation":[{"name":"Unit of Dermatology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Unit of Dermatology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Alberti","family":"Violetti","sequence":"additional","affiliation":[{"name":"Unit of Dermatology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105\u20101873.2004.00445.x"},{"key":"e_1_2_6_3_1","unstructured":"World Health Organization.The use of WHO\u2010UMC system for standardised case causality assessment. 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