{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T09:55:37Z","timestamp":1753437337610,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Infantile haemangiomas (IH) are common benign tumours of childhood. The current guideline recommended treatment is oral propranolol, the use of which for IH is relatively recent and there are no safety audits in Australian children published. As a result, it is a primarily inpatient initiated treatment. The aim of this study was to examine the short\u2010term complication rates in infants treated with oral propranolol for IH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective case note review of IH patients initiated on oral propranolol admitted to the day\u2010unit of tertiary metropolitan hospital in an Australia capital city, from January 2016 to December 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 72 children were included in the study. Mean age at time of admission was 3.8\u2009\u00b1\u20092\u00a0months. Eight patients (11.1%) experienced complications during their initiation admission. Pulmonary complications (oxygen desaturation, wheeze, increased respiratory rate) was the most common type. No children required high\u2010dependency or intensive care unit admission. The children who experienced complications had a mean age of 2.4\u2009\u00b1\u20091.2\u00a0months; <jats:italic>t<\/jats:italic>\u2010test of equality of means found a relationship between propranolol\u2010associated complication rate and age (<jats:italic>p<\/jats:italic>\u00a0=\u20090.007). All other patient or admission characteristics were not associated with complication events (all <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Propranolol is a safe, effective and well\u2010tolerated treatment in Australian children with IH. This study demonstrates younger infants will most likely benefit from inpatient initiation. More research needs to be done to characterise the risk profile of propranolol initiation for IH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13906","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T10:19:42Z","timestamp":1659953982000},"page":"473-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Immediate possible adverse event rates in infants treated with oral propranolol for infantile haemangiomas at an Australian urban tertiary hospital between 2016 and 2019"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2748-3383","authenticated-orcid":false,"given":"Lucinda","family":"Adams","sequence":"first","affiliation":[{"name":"Division of Medicine University of Adelaide  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Ryan","sequence":"additional","affiliation":[{"name":"Division of Medicine University of Adelaide  Adelaide South Australia Australia"},{"name":"Dermatology Department Women's and Children's Hospital  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015\u20102485"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.08.019"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2008.00626.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14743"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318208d2ac"},{"issue":"2","key":"e_1_2_9_7_1","first-page":"83","article-title":"The synergistic effect of bleomycin, triamcinolone and epinephrine in treatment of hemangioma and arteriovenous malformations","volume":"1","author":"Masiha H","year":"2012","journal-title":"World J Plastic Surgery"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/850193"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-0353"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2021.0454"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12089"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12156"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1691"},{"key":"e_1_2_9_14_1","unstructured":"GuidelinesSAPCP.Propranolol in infantile Haemangioma. In:wellbeing DfHa editor.Adelaide:Government of South Australia;2019."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12182"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0029"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13378"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12217"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404710"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12189"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2020008"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.0469"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.08.020"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild\u20102014\u2010306514"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922814535660"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138100"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/94136"},{"issue":"1","key":"e_1_2_9_28_1","first-page":"16","article-title":"Propranolol for infantile haemangioma: a review of current dosing regime in a regional paediatric hospital","volume":"82","author":"McGee P","year":"2013","journal-title":"Ulster Med J"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010015\u20102570\u20100"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.013"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.13906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajd.13906","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.13906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:14:07Z","timestamp":1692638047000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.13906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,8]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/ajd.13906"],"URL":"https:\/\/doi.org\/10.1111\/ajd.13906","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"type":"print","value":"0004-8380"},{"type":"electronic","value":"1440-0960"}],"subject":[],"published":{"date-parts":[[2022,8,8]]},"assertion":[{"value":"2022-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}