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Genetic background is recognized as crucial in its pathophysiology, while immunosuppression and ultraviolet radiation represent triggering factors. We report the case of a woman who developed disseminate superficial actinic porokeratosis following the intake of hydroxyurea for a polycythaemia vera. Clinical, dermoscopic and histopathology data are showed, and the role of drug as a second\u2010hit mutation trigger is discussed.<\/jats:p>","DOI":"10.1111\/ajd.13943","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T04:32:26Z","timestamp":1667363546000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Disseminated superficial actinic porokeratosis following hydroxyurea treatment: A case report"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7015-8319","authenticated-orcid":false,"given":"Maurizio","family":"Romagnuolo","sequence":"first","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano  Milan 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