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Though previously associated with drugs and infections, discussions on the association between TEN\/SJS and COVID\u201019 have been limited. We present a review of TEN\/SJS after COVID\u201019 infection and vaccination. Literature searches were conducted on PubMed and Google Scholar from 2019 to 8\/2022. Thirty\u2010eight articles were selected based on subject relevance, and references within selected articles were also screened for relevance. As of 8\/2022, there have been 34 published cases of TEN, SJS, and SJS\u2010TEN overlap after COVID\u201019 infection and vaccination, including 12 cases after vaccination and 22 cases after infection. Multiple authors hypothesize that virotopes or excipients in COVID\u201019 vaccines can activate T\u2010cells or cytokines to induce TEN\/SJS. Meanwhile, some hypothesize that COVID\u201019 infection induces immune activation that can trigger TEN\/SJS or increase susceptibility to drug\u2010induced TEN\/SJS. Treatments for post\u2010infection and post\u2010vaccination TEN\/SJS vary significantly. We recommend remaining vigilant for this rare and severe potential complication.<\/jats:p>","DOI":"10.1111\/ajd.13958","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T14:23:38Z","timestamp":1670595818000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Toxic epidermal necrolysis and <scp>Stevens\u2010Johnson<\/scp> syndrome after <scp>COVID<\/scp>\u201019 infection and vaccination"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0041-3839","authenticated-orcid":false,"given":"Henry","family":"Zou","sequence":"first","affiliation":[{"name":"Michigan State University College of Human Medicine  Grand Rapids Michigan 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