{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:35:55Z","timestamp":1747182955978,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tumour characteristics such as thickness and ulceration, along with sentinel lymph node (SLN) status, have been essential in predicting survival in patients with locally invasive melanomas at the time of diagnosis. It is unclear if these prognostic factors are relevant 1, 2 or 5\u2009years after diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The key aim of this project was to analyse conditional survival in a cohort of Queensland patients with stage IB to IIIA melanomas (American Joint Committee on Cancer's staging system, 8th version) and to test the relevance of clinicopathological prognostic factors for melanoma outcome after varying intervals of survival time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with primary invasive cutaneous melanoma who were referred to a tertiary melanoma clinic and underwent SLN biopsy between 1994 and 2011 were ascertained. The effect of patient and tumour characteristics on melanoma survival were calculated using multivariate Cox proportional hazard models at diagnosis and at variable times after diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final analysis included 651 patients (average age 49\u2009years, 55.5% male) with stage IB to IIIA melanoma. At diagnosis, and after 1 and 2\u2009years survived, SLN positivity, thickness and ulceration were predictive of 10\u2010year survival since diagnosis. However, once patients survived 5\u2009years, only SLN status was predictive. Overall conditional melanoma survival improved with increasing time survived. Five years after diagnosis, 10\u2010year conditional melanoma survival (MSS) was 91% (95% CI 86%\u201395%) compared with 85% (82%\u201388%) predicted at diagnosis. The improvement in MSS was observed mainly for Stage II melanoma patients and not for those with a positive SLN biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study confirms the improvement of prognosis according to time survived since diagnosis suggesting that after 5\u2009years survival the classic prognostic indicators may not have the same influence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.13974","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T11:40:10Z","timestamp":1674042010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Conditional survival in patients with stage IB\u2010IIIA melanoma undergoing sentinel node biopsy in Queensland: A longitudinal study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9929-2784","authenticated-orcid":false,"given":"Alexander James","family":"Tedman","sequence":"first","affiliation":[{"name":"School of Medicine The University of Queensland  Herston Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4588-4084","authenticated-orcid":false,"given":"Upekha E.","family":"Liyanage","sequence":"additional","affiliation":[{"name":"Diamantina Institute, Translational Research Institute The University of Queensland  Woolloongabba Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4813-2486","authenticated-orcid":false,"given":"Sharene","family":"Chong","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Queensland  Herston Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casey","family":"Rowe","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Queensland  Herston Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1327-7386","authenticated-orcid":false,"given":"Lena A.","family":"von Schuckmann","sequence":"additional","affiliation":[{"name":"School of Public Health The University of Queensland  Brisbane Australia"},{"name":"UQ Frazer Institute, Translational Research Institute The University of Queensland  Woolloongabba Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7879-3918","authenticated-orcid":false,"given":"Maryrose","family":"Malt","sequence":"additional","affiliation":[{"name":"Population Health Department QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2753-4841","authenticated-orcid":false,"given":"Adele C.","family":"Green","sequence":"additional","affiliation":[{"name":"Population Health Department QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"},{"name":"CRUK Manchester Institute and Faculty of Biology, Medicine and Health University of Manchester, Manchester Academic Health Sciences Centre  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8333-8685","authenticated-orcid":false,"given":"B. Mark","family":"Smithers","sequence":"additional","affiliation":[{"name":"Academy of Surgery University of Queensland, Queensland Melanoma Project, Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6406-4076","authenticated-orcid":false,"given":"Kiarash","family":"Khosrotehrani","sequence":"additional","affiliation":[{"name":"Diamantina Institute, Translational Research Institute The University of Queensland  Woolloongabba Queensland Australia"},{"name":"Department of Dermatology Princess Alexandra Hospital  Woolloongabba Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27616"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29670"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31141"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21409"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-0965-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000479"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19015"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1051-y"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24966"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-460"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000213"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers8020020"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.71.9393"},{"volume-title":"IBM SPSS Statistics for Macintosh Version 25. 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