{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T13:03:40Z","timestamp":1784207020544,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We herein present a unique patient of Netherton syndrome (NS) with ichthyosis linearis circumflexa (ILC) lesions associated with severe atopic manifestations since infancy, showing different responses of atopic and ILC lesions to a 2\u2010year dupilumab therapy. The atopic eczematous lesions and pruritus healed remarkably, dramatically improving the patient's quality of life, whilst the scalp hair showed a clinical and light microscopic improvement. The additional recovery in axillary\/pubic\/extremity hair growth, sweating and nail growth in the presented case was not previously reported in NS patients treated with dupilumab. However, dupilumab had no therapeutic effect on ILC lesions which were not pruritic and showed a treatment\u2010independent wax and waned course.<\/jats:p>","DOI":"10.1111\/ajd.13986","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T16:29:02Z","timestamp":1675700942000},"page":"272-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Long\u2010term dupilumab therapy in Netherton syndrome with severe atopic manifestations: Case report and review of the literature"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9585-9509","authenticated-orcid":false,"given":"Esen","family":"\u00d6zkaya","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, \u0130stanbul Faculty of Medicine \u0130stanbul University  \u0130stanbul 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\u0130stanbul Faculty of Medicine \u0130stanbul University  \u0130stanbul Turkey"},{"name":"Department of Dermatology and Venereology, Faculty of Medicine \u00c7anakkale Onsekiz Mart University  \u00c7anakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5617-1229","authenticated-orcid":false,"given":"Mehmet Onur","family":"G\u00f6kalp","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, \u0130stanbul Faculty of Medicine \u0130stanbul University  \u0130stanbul 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