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Despite its well\u2010understood autoimmune pathogenesis, the targets for effective cytokine intervention remain unclear. Current first\u2010line treatments include oral or topical corticosteroids, calcineurin inhibitors and phototherapy. These treatments are limited, have varying efficacies, and are associated with significant adverse events or can be time\u2010consuming. Therefore, biologics should be explored as a potential treatment for vitiligo. There are currently limited data for the use of JAK and IL\u201023 inhibitors for vitiligo. A total of 25 studies were identified in the review. 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