{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:36:11Z","timestamp":1747182971926,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acne vulgaris, a common dermatological condition that affects most adolescents and young adults, can indicate an underlying pathology if present prematurely in mid\u2010childhood. Premature acne can be caused by premature adrenarche secondary to non\u2010classical congenital adrenal hyperplasia (NC\u2010CAH), a condition arising from 21\u2010hydroxylase deficiency. This report describes a pair of monozygotic twin brothers with identical premature onset of acne, who were found to have an identical homozygous mutation in the promoter region of the CYP21A2 gene. While it is widely known that NCCAH is associated with genetic changes, the drive behind onset of adrenarche are widely unknown. As such, this report provokes thoughts on whether adrenarche could be influenced by adrenal genetic polymorphisms.<\/jats:p>","DOI":"10.1111\/ajd.14117","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T10:11:24Z","timestamp":1688119884000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Monozygotic twins with identical premature timing of acne onset: A Case report"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5984-7138","authenticated-orcid":false,"given":"Amanda S. H.","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Paediatrics KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5005-3499","authenticated-orcid":false,"given":"Shi Yun","family":"Chia","sequence":"additional","affiliation":[{"name":"Department of Dermatology KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3253-2768","authenticated-orcid":false,"given":"Jiin Ying","family":"Lim","sequence":"additional","affiliation":[{"name":"Genetic Service, Department of Paediatrics KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Chan","sequence":"additional","affiliation":[{"name":"Endocrinology Service, Department of Paediatrics KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000067817"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0490B"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-300011"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01865"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321223"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-018-0319-y"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2001.590501.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2163"},{"key":"e_1_2_4_10_1","first-page":"40","article-title":"Genetic defects in the CYP21A2 gene in heterozygous girls with premature adrenarche and adolescent females with hyperandrogenemia","volume":"210","author":"Neocleous V","year":"2012","journal-title":"Georgian Med News"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101414"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.14117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T01:06:40Z","timestamp":1697072800000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.14117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,30]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/ajd.14117"],"URL":"https:\/\/doi.org\/10.1111\/ajd.14117","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"type":"print","value":"0004-8380"},{"type":"electronic","value":"1440-0960"}],"subject":[],"published":{"date-parts":[[2023,6,30]]},"assertion":[{"value":"2023-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}