{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:51:49Z","timestamp":1783021909976,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The data in clinical practice regarding the effectiveness and safety of brodalumab in psoriasis are scarce, especially at scalp and palmoplantar locations. The main objective was the percentage of patients achieving absolute PASI \u22643\/ \u22641\/ =0 for plaque psoriasis and the percentage of patients achieving an IGA 0\u20101\/IGA 0 for the special locations at Week 52 of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Observational retrospective multicentre study in 28 Spanish Hospitals that included adult patients with plaque psoriasis treated with brodalumab, from September 2018 until March 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 200 patients were included. The mean baseline PASI was 10.97 (\u00b16.28) with a mean basal scalp (<jats:italic>n<\/jats:italic>\u2009=\u200958) and palmoplantar (<jats:italic>n<\/jats:italic>\u2009=\u200940) IGA of 2.10 (\u00b10.97) and 2.15 (\u00b11.26), respectively. At Week 52, 93.98%\/75.90%\/68.67% of patients reached an absolute PASI \u22643\/ \u22641\/ =0 in plaque psoriasis (<jats:italic>n<\/jats:italic>\u2009=\u200983), with a percentage of patients achieving scalp (<jats:italic>n<\/jats:italic>\u2009=\u200927) and palmoplantar (<jats:italic>n<\/jats:italic>\u2009=\u200919) IGA 0\u20101\/IGA 0 of 96.3%\/88.9% and 100%\/88.9%, respectively. Fifteen per cent of patients reported any adverse events with candidiasis being the most reported (6%), but only 6% of the adverse events required the withdrawal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Brodalumab demonstrated high PASI and IGA responses and was well tolerated in clinical practice in plaque, scalp and palmoplantar psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.14130","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T11:55:51Z","timestamp":1689162951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness and safety of brodalumab in the treatment of plaque, scalp and palmoplantar psoriasis: A multicentre retrospective study in a Spanish population"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9354-7464","authenticated-orcid":false,"given":"A.","family":"Sahuquillo\u2010Torralba","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitario y Polit\u00e9cnico La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2028-638X","authenticated-orcid":false,"given":"M.","family":"Hospital\u2010Gil","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Puerta del Hierro  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vilarrasa\u2010Rull","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Llamas\u2010Velasco","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de la Princesa, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IIS\u2010IP)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Rivera","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Carrascosa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari Germans Trias i Pujol, Badalona, Universidad Aut\u00f3noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"de la Cueva\u2010Dovao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Infanta Leonor  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Armesto\u2010Santos","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Marques De Valdecilla  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0381-6174","authenticated-orcid":false,"given":"R.","family":"Ru\u00edz\u2010Villaverde","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario San Cecilio  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Velasco\u2010Pastor","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Arnau de Vilanova  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-6962","authenticated-orcid":false,"given":"J.","family":"Magdaleno\u2010Tapial","sequence":"additional","affiliation":[{"name":"Department of Dermatology Consorcio Hospital General Universitario de Valencia  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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