{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:27:47Z","timestamp":1793824067538,"version":"4.6.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Most cutaneous squamous cell carcinomas (cSCC) have a good prognosis, there is a small group where metastasis and death occur and the evaluation of this risk is still cause for controversy. Tumour budding is a pattern of histological invasion that is an emerging risk factor in other solid tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the association between tumour budding and other known high\u2010risk predictors in cSCC. In addition, the impact of tumour budding on overall survival (OS) and disease\u2010specific survival (DSS) was analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Retrospective study. It included patients with a diagnosis of non\u2010genital cSCC by excisional biopsy at a university hospital, between 2010 and 2020. A pathologist re\u2010analysed their histological slides and evaluated budding. Univariate and multivariate analyses were made to study the associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>156 cSCC biopsies were found, and positive tumour budding was found in 13.5%. This correlated with worse DSS and OS. On univariate analysis, budding was correlated with the diameter, thickness of the tumour, histological grade, level of invasion, perineural and lymphovascular invasion, previous radiotherapy, recurrent tumours and lymph node metastasis (LNM). Multivariate analysis: tumour budding was associated with poorly differentiated tumours, prior radiotherapy and LNM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An association was found between tumour budding and most known risk factors in cSCC. We found findings that indicate that the presence of tumour budding is associated with a worse prognosis in terms of LNM, OS and DSS. This supports the results of previous work which has suggested that budding could be related to high\u2010risk cSCC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.14150","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T11:50:51Z","timestamp":1693828251000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Tumour budding in cutaneous squamous cell carcinoma: A novel prognosis risk factor"],"prefix":"10.1111","volume":"64","author":[{"given":"Loreto","family":"Heredia","sequence":"first","affiliation":[{"name":"Dermatology Department, Facultad de Medicina Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9388-2940","authenticated-orcid":false,"given":"Pablo","family":"Vargas\u2010Mora","sequence":"additional","affiliation":[{"name":"Dermatology Department, Facultad de Medicina Universidad de Chile  Santiago Chile"},{"name":"Melanoma and Skin Cancer Unit Instituto Nacional del C\u00e1ncer  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Jahr","sequence":"additional","affiliation":[{"name":"Dermatology Department, Facultad de Medicina Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Herranz","sequence":"additional","affiliation":[{"name":"Dermopathology Section, Pathology Service Hospital Cl\u00ednico Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3791-4696","authenticated-orcid":false,"given":"Pedro","family":"Ferrer\u2010Rosende","sequence":"additional","affiliation":[{"name":"Center for Research in Food Environments and Prevention of Diseases Associated with Nutrition Instituto de Nutrici\u00f3n y Tecnolog\u00eda de los Alimentos  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.059"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15324"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10830.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.11.037"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2009.07.007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.06.025"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23731"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.2456"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2019.06.005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.0032"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12740"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.01.015"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.94"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0422-y"},{"key":"e_1_2_8_17_1","unstructured":"BurgartL KakarS ShiC BerhoM DrimanD FitzgibbonsP.Protocol for the examination of resection specimens from patients with primary carcinoma of the colon and Rectum. 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